Results 101 to 110 of about 110,378 (294)

Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus

Autoimmunity, 2023
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. At present, the mechanism of non-coding RNA in renal injury in SLE patients is still unclear. A total of 64 DEcircRNAs, 75 DEmiRNAs, and 249 DEmRNAs were identified.
Ya Li, Juan Chen, Min Xie, Yihui Cao, Yan Zhou, Ruixian Zhang   +5 more
doaj   +1 more source

Comprehensive analysis of a long non‑coding RNA‑mediated competitive endogenous RNA network in glioblastoma multiforme

Experimental and Therapeutic Medicine, 2019
The present bioinformatics study focused on glioblastoma multiforme (GBM; grade IV glioma), a common and aggressive type of primary malignant brain tumor in adults. Long non-coding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNA) to regulate gene expression by interacting with microRNAs (miRNAs) in cancer.
Long, Shengrong, Li, Guangyu
openaire   +3 more sources

HMGA1P7-pseudogene regulates H19 and Igf2 expression by a competitive endogenous RNA mechanism [PDF]

Scientific Reports, 2016
AbstractRecent studies have revealed that pseudogene transcripts can function as competing endogenous RNAs, and thereby can also contribute to cancer when dysregulated. We have recently identified two pseudogenes, HMGA1P6 and HMGA1P7 for the HMGA1 gene whose overexpression has a critical role in cancer progression. These pseudogenes work as competitive
De Martino M, Forzati F, Marfella M, Pellecchia S, Arra C, Terracciano L, Fusco A, Esposito F   +7 more
openaire   +5 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Identification of DGUOK-AS1 as a Prognostic Factor in Breast Cancer by Bioinformatics Analysis

Frontiers in Oncology, 2020
Background: Significant developments have been made in breast cancer diagnosis and treatment, yet the prognosis remains unsatisfactory. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play pivotal roles in the development and ...
Yalun Li, Yalun Li, Yiran Liang, Tingting Ma, Qifeng Yang, Qifeng Yang   +5 more
doaj   +1 more source

Spontaneous circadian rhythms in a cold-Adapted natural isolate of Aureobasidium pullulans [PDF]

, 2017
Indexación: Scopus.Circadian systems enable organisms to synchronize their physiology to daily and seasonal environmental changes relying on endogenous pacemakers that oscillate with a period close to 24 h even in the absence of external timing cues. The
Bellora, N., Canessa, P., Franco, D.L., Larrondo, L.F., Libkind, D., Marpegan, L., Olivares-Yañez, C., Pérez-Lara, R., Risau-Gusman, S.   +8 more
core   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Research Progress of Long Non-coding RNA in Esophageal Cancer

Zhongliu Fangzhi Yanjiu, 2018
With the technological innovation of molecular biology research and the vigorous development of computer bioinformatics, the role of long non-coding RNA(lncRNA) and its biological functions have been studied intensively.It plays important roles in ...
CHEN Mengxue, LI Xueliang
doaj   +1 more source

The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers [PDF]

, 2007
Many inhibitor of apoptosis (IAP) family proteins inhibit apoptosis. IAPs contain N-terminal baculovirus IAP repeat domains and a C-terminal RING ubiquitin ligase domain.
Chen, Chun Hong, Foe, Ian, Guo, Ming, Hay, Bruce A., Huh, Jun R., Muro, Israel, Park, Jin Mo, Seol, Jae Hong, Yoo, Soon Ji   +8 more
core  

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source