Results 91 to 100 of about 2,278,547 (269)

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Competitive endogenous RNAs cannot alter microRNA function in vivo

, 2018
In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of
Broderick, Jennifer A, Zamore, Phillip D.   +1 more
core   +1 more source

Epigenetic regulation of endogenous plant pararetroviruses [PDF]

, 2005
This thesis focuses on epigenetic processes involved in the regulation of gene expression in endogenous pararetroviruses (EPRVs), exemplified by endogenous Petunia vein clearing virus (ePVCV-1) and its episomal form, PVCV. Since ePVCV-1/PVCV was found to
Noreen, Faiza
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

miR-150 in cancer metastasis: Orchestrating migration, invasion, and angiogenesis through context-dependent mechanisms

Cancer Treatment and Research Communications
Metastasis, which accounts for approximately 90 % of cancer-related mortality, is driven by intricate regulatory networks that remain only partially understood.
Belal Almajali, Waleed K. Abdulsahib, S.Renuka Jyothi, Priya Priyadarshini Nayak, Ashish Singh Chauhan, Siya Singla, Guzalya Mamedova, Fadhil Faez Sead, Pouria Salajegheh   +8 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]

, 2012
tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena, Turowski, Tomasz W., Karkusiewicz, Iwona, Kowal, J   +3 more
core   +1 more source

Comprehensive analysis of a long non‑coding RNA‑mediated competitive endogenous RNA network in glioblastoma multiforme

Experimental and Therapeutic Medicine, 2019
The present bioinformatics study focused on glioblastoma multiforme (GBM; grade IV glioma), a common and aggressive type of primary malignant brain tumor in adults. Long non-coding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNA) to regulate gene expression by interacting with microRNAs (miRNAs) in cancer.
Long, Shengrong, Li, Guangyu
openaire   +3 more sources

Sexual dimorphism in keratoconus: transcriptomic and hormonal mechanisms underlying stromal remodelling

Eye and Vision
Background Keratoconus (KC) is a vision-threatening condition with a higher prevalence and earlier onset in males than in females. The study aims to investigate sex-associated transcriptomic features of KC and assess whether sex hormones modulate stromal
Yining Sun, Qixin Li, Xiaoqing Wu, Xintong Yu, Ruoqi Wang, Binjia Sun, Kaisheng Wang, Ye Yu, Shihao Chen, Dan Jiang, Wei Chen   +10 more
doaj   +1 more source

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source