Results 71 to 80 of about 743,903 (298)
Статистика и экономика, 2016 The study volume, structure and dynamics of investment companies Moscow region will be carried out using the methods ofeconomic-statistical, financial and economic analysis, includingmethods of statistical observation methods grouping detail anddata ...
Svetlana N. Zhuravleva
doaj +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
The European Green Deal: shaping environmentally friendly policies under Article 101 TFEU
Market and Competition Law Review, 2020 In the light of the renewed general interest for environmental issues, resulting from the launch of the European Green Deal by President Von Der Leyen, the paper explores how the EU Commission could promote environmental considerations in the ...
Andrea Pezza
doaj +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
sprynger: Scriptable bibliometrics using a Python interface to Springer Nature
SoftwareXWe present a wrapper for the Springer Nature RESTful API written for Python 3. The wrapper allows users to access their free-to-use endpoints via user-friendly interfaces and can be used without prior knowledge of RESTful APIs.
Nils A. Herrmann, Michael E. Rose
doaj +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
COMPETITION ASPECTS IN THE AI ACT – NAVIGATING THE MURKY WATERS OF THE ABUSIVE PRACTICES IN A DECENTRALISED VIRTUAL WORLD [PDF]
Challenges of the Knowledge SocietyThe whole European construction, based on the three initial European Communities (namely, the European Coal and Steel Community, the European Economic Community and the European Atomic Energy Community) were built with several goals in mind, one of ...
Iulian BĂICULESCU
doaj
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Scientific ReportsThis study examined the psychometric properties of the Chinese version of the Multidimensional Competitive Orientation Inventory (Ch-MCOI) in adults from Mainland China.
Yuqian Wang +4 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source