Results 51 to 60 of about 767,407 (301)

Advancing computational biology and bioinformatics research through open innovation competitions

PLOS ONE, 2019
SummaryOpen data science and algorithm development competitions offer a unique avenue for rapid discovery of better computational strategies. We highlight three examples in computational biology and bioinformatics research where the use of competitions has yielded significant performance gains over established algorithms.
Andrea Blasco, Michael G. Endres, Rinat A. Sergeev, Anup Jonchhe, N. J. Maximilian Macaluso, Rajiv Narayan, Ted Natoli, Jin H. Paik, Bryan Briney, Chunlei Wu, Andrew I. Su, Aravind Subramanian, Karim R. Lakhani   +12 more
openaire   +5 more sources

Verification of systems biology research in the age of collaborative competition [PDF]

Nature Biotechnology, 2011
Collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results.
Meyer Pablo, Alexopoulos Leonidas G, Bonk Thomas, Califano Andrea, Cho Carolyn R, de la Fuente Alberto, de Graaf David, Hartemink Alexander J, Hoeng Julia, Ivanov Nikolai V, Koeppl Heinz, Linding Rune, Marbach Daniel, Norel Raquel, Peitsch Manuel C, Rice J Jeremy, Royyuru Ajay, Schacherer Frank, Sprengel Joerg, Stolle Katrin, Vitkup Dennis, Stolovitzky Gustavo   +21 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Proceedings of the COST SUSVAR/ECO-PB Workshop on organic plant breeding strategies and the use of molecular markers [PDF]

, 2005
In many countries,national projects are in progress to investigate the sustainable low-input approach.In the present COST network,these projects are coordinated by means of exchange of materials,establishing common methods for assessment and statistical ...

core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The Distribution of Saperda Inornata and Oberea Schaumii (Coleoptera: Cerambycidae) within the Crowns of Large Trembling Aspens, Populus Tremuloides [PDF]

, 2017
The larvae of Saperda inornata Say and Oberea schaumii LeConte inhabit the stems of trembling aspen (Populus tremuloides Michaux) root suckers and the twigs of larger trees. Nord et al.
Knight, Fred B., Nord, John C.
core   +3 more sources

Competition between Silicifiers and Non-silicifiers in the Past and Present Ocean and Its Evolutionary Impacts

Frontiers in Marine Science, 2018
Competition is a central part of the evolutionary process, and silicification is no exception: between biomineralized and non-biomineralized organisms, between siliceous and non-siliceous biomineralizing organisms, and between different silicifying ...
Katharine R. Hendry, Alan O. Marron, Flora Vincent, Daniel J. Conley, Daniel J. Conley, Marion Gehlen, Federico M. Ibarbalz, Bernard Quéguiner, Chris Bowler   +8 more
doaj   +1 more source

Shared Transcriptional Machinery at Homologous Alleles Leads to Reduced Transcription in Early Drosophila Embryos

Frontiers in Cell and Developmental Biology, 2022
The mechanism by which transcriptional machinery is recruited to enhancers and promoters to regulate gene expression is one of the most challenging and extensively studied questions in modern biology.
Hao Deng, Bomyi Lim
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Responsible and safe innovation in education: an iGEM showcase

Journal of Responsible Innovation
This paper showcases a project involved in the international Genetically Engineered Machines (iGEM) competition – a competition dedicated to the advancement of synthetic biology – executed at Delft University of Technology, the Netherlands.
Britte Bouchaut, Lotte Asveld
doaj   +1 more source