Results 81 to 90 of about 1,539,544 (287)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

open access: yesAdvanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu   +12 more
wiley   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

open access: yesAdvanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li   +16 more
wiley   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang   +5 more
wiley   +1 more source

Haemagglutinin Competition ELISA v1

open access: yes, 2019
This Competition ELISA was established to measure CR9114-like antibodies in murine serum. CR9114 is a monoclonal antibody which binds to a conserved stem region of the hemagglutinin (HA) protein of influenza viruses. As the binding site of CR9114 is conserved among a broad variety of influenza viruses it is associated with heterosubtypic protection ...
openaire   +1 more source

The Development of ELISA and SPR-Based Immunoassays for the Detection of Heat Shock Proteins. [PDF]

open access: yes, 2009
Heat shock proteins (Hsps) are highly conserved molecules in all eukaryotes and prokaryotes. They are named on the basis of their molecular weight and their synthesis is up-regulated by stress conditions such as inflammation, oxidative stress and ...
Gong, Bei
core  

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

open access: yesAdvanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo   +8 more
wiley   +1 more source

Nationwide cross-sectional study on brucellosis sero-prevalence in buffaloes using competitive ELISA

open access: yesIndian Journal of Animal Sciences
Brucellosis is a bacterial disease caused by various Brucella species, which mainly infect bovines (cattle, buffalo), small ruminants (sheep, goat), swine, and dogs and humans.
RAJESWARI SHOME   +8 more
doaj   +1 more source

Evaluation of ELISA and Brucellacapt tests for diagnosis of human Brucellosis [PDF]

open access: yes
Background and Objectives: Brucellosis is one of the most common zoonotic diseases in Iran and human brucellosis is endemic in all parts of the country. Because of the difficulty in the diagnosis of brucellosis, particularly in endemic areas, the use of ...
پیری دوگاهه, هادی   +2 more
core  

Homenaje a Elisa Mújica

open access: yes, 2022
En honor a la verdad, el centenario del nacimiento de la escritora Elisa Mújica, salvo uno que otro homenaje, paso desapercibido.
Saboyá, Elkin
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

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