Results 31 to 40 of about 1,254,653 (348)
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
FEBS Letters, EarlyView.Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera +4 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Institutional contributions to agricultural producer price stability
Agricultural and Food Economics, 2022 This paper compares the main intersectoral and national agricultural institutions in Russia and Switzerland during the period 2004–2019 and uses data from the Food and Agriculture Organization (FAO), an ordinary least squares model and fixed-effects ...
Daria Loginova, Stefan Mann
doaj +1 more source
Why emerging leaders should focus on being good postdoctoral supervisors
FEBS Letters, EarlyView.Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski +5 more
wiley +1 more source
Unlocking the Code to Continuous Innovation: A Study of Key Determinants for Serial Innovators
Administrative SciencesThis study investigates the fundamental role of collaboration in promoting a culture of continuous innovation in companies, driving them to become serial innovators, as evidenced by their industrial property registrations. Furthermore, it explores, in an
Cátia Rosário +2 more
doaj +1 more source
The Economics of Small States; Observations from Scotland - a Comment
Welsh Economic Review, 2016 The historical perspective provided by John Kay in his article presents a compelling rationale for re-thinking what a state is and what it should do. The production relationships and consumption patterns that characterise today’s interconnected global ...
James R. Wilson
doaj +1 more source
The Inner Functioning of Local Governance Networks in Centralized Countries: A ‘Brave New World’?
Social Sciences, 2023 Local governance networks are increasingly seen as the big idea to cope with issues that are complex enough in scope and scale to require a diversity of expertise and resources. While conventional narrative has posited that local networks are optimal for
Patrícia Silva +4 more
doaj +1 more source
Demographic change and regional competitiveness: The effects of immigration and ageing [PDF]
, 2007 The demographic profile of a region is usually seen as a slowly changing background phenomenon in the analysis of regional competitiveness and regional growth. However, regional demographic change can have a significant impact on regional competitiveness
Poot, Jacques
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source