Results 201 to 210 of about 68,113 (243)
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Microcalorimetry as a tool for the detection of complement-dependent cytotoxicity
Journal of Immunological Methods, 1985Microcalorimetry using a 4-channel static ampoule microcalorimeter of thermopile type has been evaluated as a tool for the detection of complement-dependent cytotoxicity against the surface antigens of living cells. Cytotoxic reactions mediated by a rabbit antiserum against human white blood cells and by 2 different monoclonal antibodies recognizing a ...
R Fäldt, J Ankerst, H O Sjögren
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Immunotherapy, 2013
Novel treatments for metastatic melanoma are urgently needed.We developed radioimmunotherapy of metastatic melanoma using 6D2 monoclonal antibody (mAb) to melanin with encouraging therapeutic results, preclinically and in patients.We observed tumor suppression with the unlabeled 6D2 mAb and investigated its tumoricidal mechanisms.
Ekaterina Dadachova +2 more
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Novel treatments for metastatic melanoma are urgently needed.We developed radioimmunotherapy of metastatic melanoma using 6D2 monoclonal antibody (mAb) to melanin with encouraging therapeutic results, preclinically and in patients.We observed tumor suppression with the unlabeled 6D2 mAb and investigated its tumoricidal mechanisms.
Ekaterina Dadachova +2 more
exaly +3 more sources
Complement-Dependent Cytotoxicity Assay
Cold Spring Harbor Protocols, 2018A useful feature of therapeutic antibodies is the ability to kill the cells to which they bind. Antibodies are capable of mediating cell killing in a variety of ways. Apoptosis, complement-mediated mechanisms, and antibody-dependent cellular cytotoxicity are all effects that can be assayed to characterize lead antibody candidates.
Thomas D, Duensing, Susan R, Watson
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Complement-Dependent Cytotoxicity Crossmatch
2013The complement-dependent cytotoxic crossmatch is an informative test that detects alloantibodies in pre- and post-transplant patients, which may dictate clinical management of transplant patients. While challenging to perform, the cytotoxic crossmatch represents the only assay that provides direct evidence for the presence of potentially pathologic (i ...
Jeremy Ryan, Peña +2 more
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Monoclonal anticolon carcinoma antibodies in complement‐dependent cytotoxicity
International Journal of Cancer, 1981AbstractHybridoma‐derived monoclonal anticolon carcinoma (ACC) antibodies mediated specific complement‐dependent cytotoxicity (CDC) against human colon carcinoma cells either grown in culture or obtained directly from patients. These ACC antibodies did not lyse normal colonic mucosa or other normal and malignant human cells.
D M, Herlyn, H, Koprowski
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Complement-Dependent Cytotoxicity for Negative Selection at the mRNA Level
Immunological Investigations, 1992Complement-Dependent Cytotoxicity (CDC) is a common technique used for isolating and characterizing cell populations. However, the molecular events resulting from CDC-mediated cell injury remain obscure. In order to use CDC as a selection procedure for studies at the RNA level, we examined if CDC is associated with rapid degradation of RNAs from target
Gill, N. S. +2 more
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Enhanced cytotoxicity of amyloid β-peptide by a complement dependent mechanism
Neuroscience Letters, 1994Amyloid beta-peptide (A beta) has been shown to activate the classical complement pathway in vitro. Here, we demonstrate that this interaction is fully capable of killing cells and damaging cellular processes in mixed hippocampal cultures from embryonic day 18 rat fetuses.
J, Schultz +6 more
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Complement-dependent phagocytosis as a regulator of antibody-dependent cellular cytotoxicity
The Journal of Immunology, 2022Abstract While monoclonal antibodies (mAb), such as αCD20, have significantly improved patient outcomes for B cell malignancies, patient responses vary and drug resistance can occur. One proposed limitation is the reduction of innate immune effector functions such as antibody dependent cellular phagocytosis (ADCP) – the principal ...
Carly M Van Wagoner +6 more
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Separation of complement‐dependent and lymphocytedependent cytotoxic activity in human sera
European Journal of Immunology, 1975AbstractTwo human sera having both complement‐dependent and lymphocyte‐dependent antibody activities (CDA, LDA) were applied to isoelectrofocusing columns. Maximum LDA activity for both sera was found focused at a higher pH than maximum CDA activity. The studies suggest that LDA molecules may exist without having complement‐dependent activity.
J L, Miller, D L, Mann, I, Yust
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Complement‐dependent cytotoxic antibodies in the course of cervical carcinoma
International Journal of Cancer, 1977AbstractComplement‐dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me‐180, SW‐732 and HeLa) and to Herpes simplex virus type 2 (HSV‐2)‐infected cells were determined in a long‐term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma cell lines and HSV‐2 ...
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