This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Direct Switch From Iptacopan to Pegcetacoplan in a Patient With Paroxysmal Nocturnal Hemoglobinuria. [PDF]
Latyshev V +3 more
europepmc +1 more source
Micro Complement Fixation Assay for Type-Specific Group A Streptococcal Antibody [PDF]
M. Wittner, Eugene N. Fox
openalex +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Peripheral complement C3 and C4 are associated with clinical features of schizophrenia. [PDF]
Szwajca M +5 more
europepmc +1 more source
Asymptotic preserving IMEX-DG-S schemes for linear kinetic transport equations based on Schur complement [PDF]
Zhichao Peng, Fengyan Li
openalex +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Thrombotic Microangiopathy And Hypertensive Emergency After Cocaine Use: A Case Report. [PDF]
Moreno-Mirón JM +4 more
europepmc +1 more source
Studying the structural basis for selectivity in complexes of peptide inhibitors and serine proteases of the complement system [PDF]
Zsolt Dürvanger +10 more
openalex +1 more source

