Results 171 to 180 of about 2,630,357 (343)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Peripheral complement C3 and C4 are associated with clinical features of schizophrenia. [PDF]

open access: yesFront Psychiatry
Szwajca M   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Thrombotic Microangiopathy And Hypertensive Emergency After Cocaine Use: A Case Report. [PDF]

open access: yesJ Brown Hosp Med
Moreno-Mirón JM   +4 more
europepmc   +1 more source

Studying the structural basis for selectivity in complexes of peptide inhibitors and serine proteases of the complement system [PDF]

open access: bronze, 2019
Zsolt Dürvanger   +10 more
openalex   +1 more source

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