Results 191 to 200 of about 776,284 (248)

Translational immunothrombosis in autoimmune Heparin-Induced thrombocytopenia: targeting the FcγRIIa-Syk-BTK and complement pathways. [PDF]

Clin Exp Med
Ahmadinia M, Askarzade A, Afsharara H, Gholizadeh Niari B, Jamali F, Farasatinasab M.   +5 more
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer. [PDF]

Clin Transl Med
Bennion A, Lysaght J, Lynam-Lennon N.
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Divergent roles for complement components C3 and C4 in controlling <i>Klebsiella pneumoniae</i> gut colonization and systemic dissemination. [PDF]

mBio
Valencia-Bacca JD, Jennings-Gee JE, Nutter NA, Adams-Sims AE, Hegarty AA, Nzuki HL, Nagpal RK, Zafar MA, Haas KM.   +8 more
europepmc   +1 more source

LBO2 Long-term renal and cardiovascular risks of tacrolimus in lupus nephritis patients

Lupus Science and Medicine
Obbo W Bredewold, Ton J Rabelink, YK Onno Teng, Joris I Rotmans, Mieke van Schaik, Merel Priester, Wieneke M Michels   +6 more
doaj   +1 more source

A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria. [PDF]

Immunity
Opi DH, Longley RJ, Takashima E, Spelman T, Tayipto Y, Schoffer K, Brewster J, Reiling L, Wines BD, Kiniboro B, Siba P, Harbers M, Hogarth M, Tsuboi T, Robinson LJ, Mueller I, Beeson JG.   +16 more
europepmc   +1 more source