Results 131 to 140 of about 48,485 (265)

Solution-Phase Nuclear Magnetic Resonance Studies of a Nonribosomal Peptide Synthetase Adenylation Domain, of a Bacterial Glycosyltransferase, and the Rational Design of Inhibitors and Mutants of Glycosyltransferases

, 2015
A molecule's biological function is determined by its chemical structure and its three dimensional (3D) shape. While a molecule's chemical structure is fairly static its physical 3D structure is typically very dynamic and thus more difficult to determine.
MacMaster, John Samuel
core  

Editorial: Innate and adaptive immunity in normal and adverse pregnancy. [PDF]

Front Immunol
Yasmin H, Agostinis C, Bulla R, Kishore U.   +3 more
europepmc   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Bioluminescence activated by antibody-enzyme fragment complementation following target engagement

Frontiers in Bioengineering and Biotechnology, 2016
Dixon Andrew, Baumgartner Brett, Krippner Sylvia, Owen Shawn   +3 more
openaire   +1 more source

Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment. [PDF]

Front Aging
Kou W, Lu X, Zhang Z, Liu K, Liu Z, Jiang B, Wang H, Li J, Lu H, Guo C, Cao L, Zhang X.   +11 more
europepmc   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Studies on immunology of Leishmania mexicana

, 2007
Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects.
Rezvan, H, Rezvan, Hossein
core  

The role of neutrophil extracellular traps in antiphospholipid syndrome. [PDF]

Front Immunol
Ren C, Su Y, Li H, Ren T.
europepmc   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source