Results 321 to 330 of about 4,342,004 (341)
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Ficolins in complement activation
Molecular Immunology, 2013Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc).
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Haemolytic complement activity in infants
Zeitschrift f�r Kinderheilkunde, 1973In 111 sera of sick and 30 sera of healthy infants aged 14 days to 12 months hemolytic activity of complement was estimated photometrically as described by Kabat, titres being expressed in 50% hemolytic units (C′H50).
M, Büsse, J, Ströder
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Assays for Complement Activation
Clinics in Laboratory Medicine, 1986Complement is a major biologic mediation system that functions in host defense against microorganisms and other pathogens and also aids in the elimination of damaged and abnormal cells. This is accomplished by its ability to mediate the destruction of pathogens and altered cells directly through cytolytic and cytotoxic properties, as well as indirectly
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Activation of Complement by Endotoxin
Journal of Infectious Diseases, 1973Ovine erythrocytes (E) coated with endotoxin (LPS) from Salmonella typhosa 0901 have been used for characterization of the nature of a pathway by which LPS activates complement (C). E-LPS consumed C in normal guinea-pig serum in a manner identical to that in which C is consumed by LPS, that is, with marked consumption of C3-C9 and little depletion of ...
S E, Mergenhagen +2 more
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Mathematical studies of complement activation
Clinica Chimica Acta, 1983Kinetic studies of complement activation were followed by hemolytic assay. Mathematical analysis shows that the curve is composed of two exponents: the first one, which occurs during a short span of time, represents the classical pathway, the second the alternative pathway.
M A, Garrigue, J P, Muh, P, Bardos
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Monomeric Complement-Activating IgG Paraproteins
The Journal of Immunology, 1999AbstractThree patients presented a unique syndrome of recurrent panniculitis with an IgGκ paraprotein and depletion of the early components of the classical pathway of complement. The IgGκ paraproteins were monomers with a normal structure, and with no evidence for aggregation, as assessed by electron microscopy and ultracentrifugation.
M, Trendelenburg +5 more
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Examining coagulation-complement crosstalk: complement activation and thrombosis
Thrombosis Research, 2016The coagulation and complement systems are ancestrally related enzymatic cascades of the blood. Although their primary purposes have diverged over the past few hundred million years, they remain inextricably connected. Both complement and coagulation systems limit infection by pathogens through innate immune mechanisms. Recently, it has been shown that
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Complement Activation by Cold Agglutinins
Vox Sanguinis, 1992AbstractPurified monoclonal human IgM cold agglutinins (CA) of different specificities (anti‐I, anti‐i, anti‐Pr) were investigated for their complement‐activating capacity in a homologous system. Incubation of human RBC with excess of IgM CA in the cold, and subsequently with human serum at 37°C, resulted in striking differences in hemolysis. Hemolysis
M, Kirschfink, H, Fritze, D, Roelcke
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Complement Activation in Renal Disease
Uremia Investigation, 1984Perturbation of the serum complement system in glomerulonephritis can be the result of classical pathway activation by immune complexes or of C3 activation by the C3-C5 convertase stabilized by the C3 nephritic factor. Low C3 levels can also be the result of diminished C3 synthesis and possibly, in certain circumstances, of C3 convertases deposited on ...
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