Results 371 to 380 of about 4,621,354 (401)
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Initiation of Complement Activation
Springer Seminars in Immunopathology, 1984The complement system is an excellent one to look at as an example of a triggered enzyme system. It is found to use almost all the strategies of enzyme cascades and for initiation which were discussed in the introduction. The classical pathway is a fine example of an active zymogen form of activation and the alternative pathway is the canonical example
N. C. Hughes-Jones, P. J. Lachmann
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Activation of Complement by Endotoxin
Journal of Infectious Diseases, 1973Ovine erythrocytes (E) coated with endotoxin (LPS) from Salmonella typhosa 0901 have been used for characterization of the nature of a pathway by which LPS activates complement (C). E-LPS consumed C in normal guinea-pig serum in a manner identical to that in which C is consumed by LPS, that is, with marked consumption of C3-C9 and little depletion of ...
Stephan E. Mergenhagen +2 more
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Activation of complement by trypanosomes
Experientia, 1977Factors exhibiting anti-complementary activity released from trypanosomes after incubation at 20 degrees C were described. The active material was shown to consume the first component of bovine complement. While the anti-complementary factor(s) from T. lewisi could activate bovine, human and guinea pig complement, the factor(s) from T.
K Nielsen, J Sheppard
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Complement activation in psoriasis
Clinical and Experimental Dermatology, 1990Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in the patients with psoriasis.
William P. Kolb +4 more
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Bispecific Complement Engagers for Targeted Complement Activation
The Journal of Immunology, 2023Abstract Activation of the complement system represents an important effector mechanism of endogenous and therapeutic Abs. However, efficient complement activation is restricted to a subset of Abs due to the requirement of multivalent interactions between the Ab Fc regions and the C1 complex.
Dennis V Pedersen +9 more
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Complement activation and atherosclerosis
Molecular Immunology, 1999Atherosclerosis is an inflammatory disease mediated through the action of monocyte/macrophages, complement and T-lymphocytes. C5a and monocyte chemotactic factor released during complement activation in the arterial wall may participate in the initial monocyte recruitment. Assembly of C5b-9 on cells of the arterial wall may also induce cell lysis.
Florin Niculescu, Horea Rus
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Complement activation in pneumonia
Medical Microbiology and Immunology, 1979Complement analyses performed on serially collected plasma samples from 10 patients during acute infectious pneumonia or bronchopneumonia showed normal or increased values for hemolytic activity and Clq, C4, C3, and factor B levels. However, the levels of C3 breakdown products (C3d) were significantly (greater than 2 SD) increased in six patients ...
Rudolf H. Zubler +9 more
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COMPLEMENT ACTIVATION IN MIGRAINE
The Lancet, 1977Forty patients attending the Prince Henry Hospital migraine clinic have been investigated for evidence of complement activation related to migraine. These patients had a history of clinically similar migraine attacks. Levels of serum complement components were determined in nine patients, both in and out of migraine.
T.W. Duckworth +2 more
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Activation of complement by Naegleria
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980Neither Naegleria nor its culture supernatant was found to be directly chemotactic for human neutrophils. Interaction of Naegleria with human serum, however, resulted in the generation of a strong chemotactic stimulus. The reduction of serum activity by heat-inactivation indicated a dependence on serum complement for the interaction.
Brenton Rowan-Kelly +2 more
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The Journal of Immunology, 1962
Summary A test has been devised to measure hemolytic complement activity of mouse serum. The chief requirement for detecting mouse hemolytic complement is the use of extremely large amounts of sensitizing antibody. The hemolytic factor measured in mouse serum is indeed complement.
Rosenberg, L T, Tachibana, D K
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Summary A test has been devised to measure hemolytic complement activity of mouse serum. The chief requirement for detecting mouse hemolytic complement is the use of extremely large amounts of sensitizing antibody. The hemolytic factor measured in mouse serum is indeed complement.
Rosenberg, L T, Tachibana, D K
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