Results 381 to 390 of about 4,621,354 (401)

Complement activation, a threat to pregnancy

Journal of Reproductive Immunology, 2017
Pregnancy poses a challenge for the immune systems of placental mammals. As fetal tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the fetus and the placenta might be subject to complement-mediated immune attack with the potential risk of adverse pregnancy outcomes.
G. Girardi
semanticscholar   +6 more sources

Complement Activation and Pregnancy Failure

Clinical Reviews in Allergy & Immunology, 2009
Pregnancy represents a physiologic condition where maternal immune system tolerates the semi-allogenic fetus. The fetal tissues are directly exposed to the maternal blood with potential attacks from maternal immune system, including the activation of complement cascade. Small amounts, of both early and late components, of complement are physiologically
TINCANI, Angela, CAVAZZANA, Ilaria, ZIGLIOLI, Tamara, LOJACONO, Andrea, De Angelis V, Meroni P.   +5 more
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Assays for Complement Activation

Clinics in Laboratory Medicine, 1986
Complement is a major biologic mediation system that functions in host defense against microorganisms and other pathogens and also aids in the elimination of damaged and abnormal cells. This is accomplished by its ability to mediate the destruction of pathogens and altered cells directly through cytolytic and cytotoxic properties, as well as indirectly
openaire   +3 more sources

Biological Activities of Complement

Biochemical Society Transactions, 1978
Complement is a system of serum proteins whose main function is to defend the body against infection. Although it has a reputation as a dauntingly complex system, this results chiefly from confusion in the nomenclature, which has varied considerably with time as more components were discovered, for example as ‘component C3’ became subdivided into ...
openaire   +3 more sources

Complement activation in hypercholesterolemia.

Nutrition, metabolism, and cardiovascular diseases : NMCD, 2000
Inflammatory and lipid factors share an important role in atherosclerosis. This study evaluates their relations in dyslipidemic subjects.We compared the complement system (serum hemolytic activity CH50, C3 and C4 fractions and terminal complex sC5b-9) in 30 hypercholesterolemic patients with elevated cholesterol and decreased HDL-cholesterol levels, 30
PASQUI A. L., BOVA G., PUCCETTI L., BRUNI F., POMPELLA G., AUTERI A.   +5 more
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Ficolins in complement activation

Molecular Immunology, 2013
Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc).
openaire   +3 more sources

Activation of the Complement System

1973
The complement system is a mediator of a number of biologically important reactions which range from cytotoxicity of antibody-sensitized cells, bacteria, and viruses to mediation of inflammatory processes. The components of the system are a number of normal serum proteins which are present in the circulation as functionally inactive precursor molecules.
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Complement activation by (auto-) antibodies

Molecular Immunology, 2011
The complement system is a key part of the innate immune system and plays an important role in the clearance of pathogens and apoptotic cells upon its activation. It is well known that both IgG and IgM can activate complement via the classical pathway by binding of C1q to the Fc regions of these immunoglobulins. Recent advances have shown that also IgA
Daha, N.A., Banda, N.K., Roos, A., Beurskens, F.J., Bakker, J.M., Daha, M.R., Trouw, L.A.   +6 more
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Complement Activation and Cardiovascular Disease

Hormone and Metabolic Research, 2008
The mechanisms by which tissue injury after acute myocardial infarction occurs have not been fully elucidated, but considerable evidence suggests that activation of complement plays an important role in the pathophysiology. Reperfusion of the ischemic myocardium is strictly necessary to rescue the exposed tissue from eventual death.
Bjerre, Mette, Hansen, Troels Krarup, Flyvbjerg, A   +2 more
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Activation of the complement system

Trends in Biochemical Sciences, 1976
Abstract The complement system is activated by two distinct pathways both of which utilize the complement components C3 to C9. However, the pathways differ in their early acting components and in the manner by which these components are activated by immunoglobulins or other factors.
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