Results 101 to 110 of about 550,801 (291)

New insight into the effects of heparinoids on complement inhibition by C1-inhibitor

, 2016
Complement activation is of major importance in numerous pathological conditions. Therefore, targeted complement inhibition is a promising therapeutic strategy.
Damman, J., M R Daha, Daha, M.R., de Vrij, E. L., Leuvenink, H. G.; id_orcid, Vrij, E.L. de, J G M Burgerhof, Saye, J., Burgerhof, J.G.M., Leuvenink, H. G., H G Leuvenink, J Saye, Burgerhof, J. G. M., Daha, M. R., Seelen, M. A. J., Uknis, M. E., Uknis, M.E., E L de Vrij, M E Uknis, J Damman, M A J Seelen, Seelen, M.A.J., Leuvenink, H.G., Poppelaars, F., F Poppelaars   +24 more
core   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Early diagnosis of hereditary angioedema in children: genetic testing should be prioritized

Allergy, Asthma & Clinical Immunology
Background When a member of a family has been diagnosed with hereditary angioedema (HAE) before a child is born, the question of early diagnosis arises. Indeed, the first attacks may occur at birth.
A. Bocquet, A. Pagnier, I. Boccon-Gibod, F. Defendi, C. Dumestre-Perard, G. Hardy, Laurence Bouillet   +6 more
doaj   +1 more source

Borrelia burgdorferi ErpB and ErpQ inhibit C1 complex of the classical pathway of complement through a novel mechanism

, 2023
The complement system is an organized proteolytic cascade of dozens of proteins that functions in the recognition, opsonization, and lysis of pathogenic and altered-host cells.
Garrigues, Ryan, NC DOCKS at East Carolina University   +1 more
core  

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials

Advanced Science, EarlyView.
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan, Hengheng Zhao, Haotian Wang, Zhanjie Liu, Qian Li, Weifeng Zhang, Qingsong Zhao, Liqun Zhang, Jun Liu   +8 more
wiley   +1 more source