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Complement system in cancer: friend or foe of immunotherapy. [PDF]

open access: yesJ Immunother Cancer
Shah HK   +6 more
europepmc   +1 more source

Complement C1-inhibitor expression in Alzheimer's disease

open access: yesActa Neuropathologica, 1998
In situ and in vitro studies suggest that activation of locally produced complement factors may act as a mediator between amyloid deposits and neurodegenerative changes seen in Alzheimer's disease (AD). C1-esterase inhibitor (C1-Inh), which regulates activation of C1 of the complement classical pathway, can be detected immunohistochemically in its ...
Veerhuis, R.   +5 more
openaire   +4 more sources
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Paramyosin inhibits complement C1

The Journal of Immunology, 1992
Abstract We report here the results of studies showing that inhibition of C is a property of several invertebrate paramyosins. Paramyosins from Taenia solium, Schistosoma mansoni, and the mussel Mytilus edulis bind polymeric collagen and can be isolated from crude extracts of tissues by collagen affinity.
J P, Laclette   +7 more
openaire   +2 more sources

Inhibition of bFGF activity by complement C1s: covalent binding of C1s with bFGF

Cell Biochemistry and Function, 1998
The first complement component C1s formed large aggregates with bFGF when bFGF and C1s were incubated at 37 degrees C overnight. Under non-reducing conditions, a part of the aggregates did not penetrate into 5% polyacrylamide gel in the presence of SDS, and the rest penetrated into 5% gel but not into 12% gel.
H, Sakiyama   +3 more
openaire   +2 more sources

Kinetics of interaction of C1 inhibitor with complement C1s.

Biochemistry, 1986
The kinetics of inhibition of the complement serine protease, C1s, by its only known inhibitor, C1 inhibitor, have been measured by a variety of methods. One method continuously monitors the loss of esterolytic activity with a synthetic substrate coupled to a chromogen while another monitors the formation of a stable (covalent) complex by high-pressure
M, Lennick, S A, Brew, K C, Ingham
openaire   +1 more source

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