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Abstracts of the 14th C1-inhibitor Deficiency and Angioedema Workshop. [PDF]

Allergy Asthma Clin Immunol
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Paramyosin inhibits complement C1

The Journal of Immunology, 1992
Abstract We report here the results of studies showing that inhibition of C is a property of several invertebrate paramyosins. Paramyosins from Taenia solium, Schistosoma mansoni, and the mussel Mytilus edulis bind polymeric collagen and can be isolated from crude extracts of tissues by collagen affinity.
J P, Laclette, C B, Shoemaker, D, Richter, L, Arcos, N, Pante, C, Cohen, D, Bing, A, Nicholson-Weller   +7 more
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Complement C1-inhibitor expression in Alzheimer's disease

Acta Neuropathologica, 1998
In situ and in vitro studies suggest that activation of locally produced complement factors may act as a mediator between amyloid deposits and neurodegenerative changes seen in Alzheimer's disease (AD). C1-esterase inhibitor (C1-Inh), which regulates activation of C1 of the complement classical pathway, can be detected immunohistochemically in its ...
Veerhuis, R., Janssen, I., Hoozemans, J. J., de Groot, C. J., Hack, C. E., Eikelenboom, P.   +5 more
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Inhibition of bFGF activity by complement C1s: covalent binding of C1s with bFGF

Cell Biochemistry and Function, 1998
The first complement component C1s formed large aggregates with bFGF when bFGF and C1s were incubated at 37 degrees C overnight. Under non-reducing conditions, a part of the aggregates did not penetrate into 5% polyacrylamide gel in the presence of SDS, and the rest penetrated into 5% gel but not into 12% gel.
H, Sakiyama, K, Kaji, K, Nakagawa, K, Nagino   +3 more
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Molecular Basis of Human Complement C1s Deficiency

The Journal of Immunology, 1999
Abstract This is the first report on the molecular basis of human complement C1s deficiency. Two abnormalities in the C1s gene were identified in a Japanese family, including one patient, by using exon-specific PCR, single-strand conformation polymorphism analysis, and nucleotide sequencing. A deletion of 4 bp, TTTG, was identified in
Y, Endo, K, Kanno, M, Takahashi, K i, Yamaguchi, Y, Kohno, T, Fujita   +5 more
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Kinetics of interaction of C1 inhibitor with complement C1s.

Biochemistry, 1986
The kinetics of inhibition of the complement serine protease, C1s, by its only known inhibitor, C1 inhibitor, have been measured by a variety of methods. One method continuously monitors the loss of esterolytic activity with a synthetic substrate coupled to a chromogen while another monitors the formation of a stable (covalent) complex by high-pressure
M, Lennick, S A, Brew, K C, Ingham
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Clionasterol: A Potent Inhibitor of Complement Component C1

Planta Medica, 2003
Clionasterol (1a), clionasterol monoacetate (1b) and 5alpha,8alpha-epidioxy-24alpha-ethylcholest-6-en-3-ol (2), isolated from the marine sponge Xestospongia exigua, and beta-sitosterol (3) were tested for their influence on the classical (CP) and alternative (AP) pathways of activation of the human complement system in vitro.
Fátima, Cerqueira, Rawiwan, Watanadilok, Pichai, Sonchaeng, Anake, Kijjoa, Madalena, Pinto, Henriette, Quarles van Ufford, Burt, Kroes, Cees, Beukelman, Maria São José, Nascimento   +8 more
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Functional model of subcomponent C1 of human complement

Journal of Molecular Biology, 1986
The domain organization of the zymogen subunits of the first component of human complement C1s, C1r2 and the complex C1s-C1r2-C1s was studied by electron microscopy. In the absence of Ca2+, monomeric C1s was visualized as a dumb-bell-shaped molecule consisting of two globular domains (center-to-center distance 11 nm) connected by a rod.
V, Weiss, C, Fauser, J, Engel
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C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s.

Immunological investigations, 1991
Inactivation of human complement subcomponent C1-s by its regulator C1 inhibitor at physiological ionic strength proceeded at a 3-fold higher rate when C1-s was in the physiological C1- complex with subcomponents C1q and C1-r rather than as purified subunit.
G L, Hortin, B L, Trimpe
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