Results 31 to 40 of about 3,430 (122)

Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT)

PLoS ONE, 2018
Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic to organs and tissues. To mitigate ROS damage, organisms have evolved a variety of antioxidant systems to counteract these harmful molecules, however in certain ...
M. Gregory Rivera, P. Hair, K. Cunnion, N. Krishna   +3 more
semanticscholar   +1 more source

The pathophysiology of the complement system in leprosy [PDF]

, 1991
The complement system, which consists of a group of proteins and glycoproteins, generally serves to amplify the effects of the interaction of antigen with antibody.
Ramanathan, V D
core  

Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core  

Anti-C1-inactivator treatment of glioblastoma

OncoTarget, 2018
Purpose Glioblastoma multiforme (GBM) or astrocytoma grade IV is the most common type of primary brain tumor in adults. In the present study, we investigate the role of the complement system in the glioblastoma situation in an experimental model, since ...
Karolina Förnvik, Jonatan Ahlstedt, K. Osther, L. Salford, H. N. Redebrandt   +4 more
semanticscholar   +1 more source

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

Frontiers in Immunology, 2017
Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, U. Kishore
semanticscholar   +1 more source

Staphylococcus aureus virulence factors and disease [PDF]

, 2013
Staphylococcus aureus is a major cause of nosocomial infections worldwide, especially methicillin-resistant S. aureus. Patients subjected to broad-spectrum antibiotics and immunosuppressive therapies have higher risk of infection by this microorganism.
Batistão, Deivid W. F., Botelho, C. M., Costa, A. R., Pereira, Maria Olívia, Ribas, Rosineide M., Sousa, Ana Margarida   +5 more
core  

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

Neural Regeneration Research
JOURNAL/nrgr/04.03/01300535-202503000-00027/figure1/v/2024-06-17T092413Z/r/image-tiff Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus, leading to long-term cognitive impairment.
Jing Wang, Bing Zhang, Lanfang Li, Xiaomei Tang, Jinyu Zeng, Yige Song, Chao Xu, Kai Zhao, Guoqiang Liu, Youming Lu, Xinyan Li, Kai Shu   +11 more
semanticscholar   +1 more source

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

PLoS Pathogens, 2016
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
B. Garcia, Hui Zhi, Beau Wager, M. Höök, J. Skare   +4 more
semanticscholar   +1 more source

The Role of Exopolyphosphatase in Neisseria meningitidis Infection

, 2009
The development of vaccines against serogroup B Neisseria meningitidis to reduce the morbidity and mortality of meningococcal disease is a major public health priority.
Zhang, Qian, Zhang, Qian
core   +1 more source

Role of Serum Amyloid P Component in Immune Clearance [PDF]

, 1986
In order to clarify the mechanism of interaction of serum amyloid P component (SAP) with complement, the interaction of SAP with Clq was studied. It is known that SAP binds Sepharose 4B in the presence of calcium.
Bristow, Cindy L.
core   +1 more source