Results 91 to 100 of about 40,238 (270)

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in Immunology, 2020
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen, Dennis V. Pedersen, Heidi Gytz, Alessandra Zarantonello, Jens Magnus Bernth Jensen, Annette G. Hansen, Steffen Thiel, Gregers R. Andersen   +7 more
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Molecular Neurodegeneration, 2018
Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD).
Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli   +7 more
doaj   +1 more source

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Glia, EarlyView.
Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols. ABSTRACT Cerebral organoids derived from human induced pluripotent stem cells (iPSCs) are increasingly ...
Xabier Cuesta‐Puente, Marco Gonzalez‐Dominguez, Marta Pereira‐Iglesias, Nerea Perez‐Arriazu, Patricia Villegas‐Zafra, Paula Ramos‐Gonzalez, Fabio Cavaliere, Nora Bengoa‐Vergniory, Amanda Sierra   +8 more
wiley   +1 more source

Increased complement C1q level marks active disease in human tuberculosis. [PDF]

PLoS ONE, 2014
BackgroundComplement functions as an important host defense system and complement C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role of other complement components in tuberculosis.MethodsComplement ...
Yi Cai, Qianting Yang, Yueqiang Tang, Mingxia Zhang, Haiying Liu, Guoliang Zhang, Qunyi Deng, Jian Huang, Zhiliang Gao, Boping Zhou, Carl G Feng, Xinchun Chen   +11 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K., Fraser, Robert J., Gunn, Bronwyn M., Heise, Mark T., Herrero, Lara J., Hueston, Linda, Mahalingam, Suresh, Morrison, Thomas E., Ramirez, Ruben, Smith, Paul N., Whitmore, Alan C.   +10 more
core   +1 more source

Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma

BMC Psychiatry, 2022
Background Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation.
Xianmei Luo, Zeman Fang, Lingyun Lin, Haiyun Xu, Qingjun Huang, Handi Zhang   +5 more
doaj   +1 more source

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]

, 2019
IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M, Goetzl, Edward J, Rissman, Robert A, Schwartz, Janice B, Winston, Charisse N   +4 more
core   +2 more sources

Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis [PDF]

Frontiers in Immunology, 2018
Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack of specific biomarkers that discriminate active TB disease from other (lung) diseases or latent TB infection (LTBI). Integrated human gene expression results have shown that genes encoding complement components, in particular
Rosalie Lubbers, Jayne S. Sutherland, Delia Goletti, Roelof A. de Paus, Coline H. M. van Moorsel, Marcel Veltkamp, Stefan M. T. Vestjens, Willem J. W. Bos, Willem J. W. Bos, Linda Petrone, Franca Del Nonno, Ingeborg M. Bajema, Karin Dijkman, Frank A. W. Verreck, Gerhard Walzl, Kyra A. Gelderman, Geert H. Groeneveld, Annemieke Geluk, Tom H. M. Ottenhoff, Simone A. Joosten, Leendert A. Trouw   +20 more
openaire   +6 more sources