Results 101 to 110 of about 24,672 (204)

Complement C1q and von Willebrand factor interaction in atherosclerosis of human carotid artery. [PDF]

Front Immunol, 2023
Schulz K, Donat C, Punjabi M, Glatz K, Kaufmann B, Trendelenburg M.   +5 more
europepmc   +1 more source

Roles of Microglia in Cerebral Small Vessel Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Chronic cerebral hypoperfusion triggers microglial activation in cerebral small vessel disease (CSVD). Activated microglia drive neuroinflammation, oxidative stress, and blood–brain barrier disruption, leading to white matter hyperintensities, enlarged perivascular spaces, and other neuroimaging features.
Chenyang Jin, Xiaoqian Song, Yuewen Sun, Yilong Peng, Jing Zhou, Liyan Wang, Xinbao Yin, Xueping Zheng   +7 more
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
doaj   +1 more source

Preventive Effects of Crataegus monogyna Fruit Extract on Oxidative Damage and Inflammatory Response in a Rat Model of Acetic Acid‐Induced Ulcerative Colitis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Crataegus monogyna fruit extract attenuated oxidative stress and inflammatory responses in acetic acid‐induced ulcerative colitis in rats. Treatment improved antioxidant status, reduced lipid peroxidation, and alleviated histopathological damage, demonstrating its protective effect against ulcerative colitis.
Soumaya Wahabi, Dhekra Grami, Khaoula Gharbi, Slimen Selmi, Hichem Sebai   +4 more
wiley   +1 more source

Galectin-3 – A novel ligand of complement protein C1q

International Journal of Biological Macromolecules
In the present study we report a novel interaction of human C1q, a primary activator of the Complement system, with human Galectin-3 (Gal-3). We investigated the potential recognition between C1q and Gal-3 on a solid hydrophobic surface by ELISA, by fluorescence spectroscopy, molecular docking and molecular dynamics (MD).
Gabriela Radulova, Alexandra Kapogianni, Ginka Cholakova, Stoyan Iliev, Anela Ivanova, Vanya Bogoeva, Ivanka Tsacheva   +6 more
openaire   +2 more sources

Microglial Pruning of Excitatory Synapses in the Hippocampus Is Complement C3‐Independent in Physiological and Neuroinflammatory States

Glia, Volume 74, Issue 7, July 2026.
In development, microglia engulfment of hippocampal excitatory synapses is unperturbed in C3‐lacking mice. Peripheral inflammation induces a neuroinflammatory phenotype and synapse loss in the hippocampus independent of complement cascade activation. ABSTRACT A key feature of brain development is the refinement of exuberant synapses, known as synapse ...
Eric W. Salter, Ashish Kadia, Lijia Zhang, Jonathan S. Thacker, Sun‐Lim Choi, Liam T. Ralph, Gang Lei, Fuzi Jin, John Georgiou, Graham L. Collingridge   +9 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Proangiogenic properties of complement protein C1q can contribute to endometriosis

Frontiers in Immunology
Endometriosis (EM) is defined as the engraftment and proliferation of functional endometrial-like tissue outside the uterine cavity, leading to a chronic inflammatory condition.
Chiara Agostinis, Miriam Toffoli, Gabriella Zito, Andrea Balduit, Silvia Pegoraro, Mariagiulia Spazzapan, Lorella Pascolo, Federico Romano, Giovanni Di Lorenzo, Alessandro Mangogna, Aurora Santin, Beatrice Spedicati, Beatrice Spedicati, Erica Valencic, Giorgia Girotto, Giorgia Girotto, Giuseppe Ricci, Giuseppe Ricci, Uday Kishore, Uday Kishore, Roberta Bulla   +20 more
doaj   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
Chandipura virus (CHPV), a neurotropic arbovirus transmitted primarily by sandflies, has emerged as a significant public health concern in India following recurrent outbreaks with high pediatric fatality rates. This review highlights the virus's virology, transmission dynamics, clinical features, and the urgent need for improved diagnostics ...
Abrar Ahmad Zargar, Reena Gupta, P. Krishnamoorthy   +2 more
wiley   +1 more source