Results 101 to 110 of about 729,206 (315)

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain [PDF]

, 2017
BACKGROUND: The complement cascade not only provides protection from infection but can also mediate destructive inflammation. Complement is also involved in elimination of neuronal synapses which is essential for proper development, but can be ...
A Klos, AH Stephan, AH Stephan, AJ Tenner, Andrea J. Tenner, AP Sjoberg, AR Bialas, B Stevens, C Nilsberth, CN Parkhurst, D Ricklin, DA Fraser, DH Cribbs, DP Schafer, F Bossi, F Petry, G Hajishengallis, GR Howell, Grant R. MacGregor, H Lui, I Rozovsky, IH Cheng, J Huang, J Zhou, JA Harris, JJ Alexander, K Yasojima, KBM Reid, LG Bodea, Lila Modarresi, LM Chow, LT Roumenina, M Botto, M Ide, M Ikarashi, M Li, Maria I. Fonseca, ME Benoit, ME Benoit, ME Benoit, Melody J. Fang, MI Fonseca, MI Fonseca, MI Fonseca, Michael X. Hernandez, MJ Vasek, MK Khoury, NC Shaner, OL Brekke, P Young, Pooja Selvan, Q Shi, R Bulla, R Fan, R Feil, R Veerhuis, S Hong, S Jung, S Yona, SD Webster, Shu-Hui Chu, SS Bohlson, T Abe, T Armbrust, T Wyss-Coray, TD Schmittgen, VH Perry, Y Chu, Y Miura-Shimura, Y Shen   +69 more
core   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]

, 2016
Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core   +4 more sources

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Biotechnology and Bioengineering, EarlyView.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal, Erica Fratz‐Berilla, Casey Kohnhorst, David N. Powers, Shishir P. S. Chundawat   +4 more
wiley   +1 more source

Xixin Decoction May Treat Vascular Dementia by Modulating the NPTX2/C1q/C3 Complement Pathway

Chemistry &Biodiversity, EarlyView.
To establish a VaD model, SD rats underwent unilateral common carotid artery ligation, followed by gavage treatment with Xixin decoction. Cognitive abilities of the rats were assessed through Morris water maze and new object recognition. Pathological changes were observed using electron microscopy observation, Golgi staining, and Nissl staining ...
Shuo Yang, Xin‐qi Gao, Ai‐hua Tan, Pan Ge   +3 more
wiley   +1 more source

The C1q binding activity of IgG is modified in vitro by reactive oxygen species: implications for rheumatoid arthritis [PDF]

, 1996
IgG can be denatured in vitro by reactive oxygen species (ROS). Native IgG activates the complement cascade through C1q. Using a modified ELISA, C1q binding activity of rheumatoid IgG has been compared to IgG denatured by neutrophil-derived ROS.
Griffiths, H.R., Lunec, J.
core   +1 more source

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Antioxidants and Redox Signaling, 2015
Aims: Loss-of-function mutations in GBA1, which cause the autosomal recessive lysosomal storage disease, Gaucher disease (GD), are also a key genetic risk factor for the α-synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy ...
E. Rocha, Gaynor A. Smith, Eric Park, H. Cao, A. Graham, Eilish Brown, J. McLean, Melissa A. Hayes, Jonathan A. Beagan, Sarah C. Izen, E. Pérez-Torres, P. Hallett, O. Isacson   +12 more
semanticscholar   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

The role of complement C1q in atrial fibrillation: a marker for disease progression and surgical outcomes

Frontiers in Cardiovascular Medicine
Background and objectiveThe complement system plays a crucial role in the pathogenesis and progression of cardiovascular diseases. C1q, a key initiator of the classical pathway, is closely associated with various chronic inflammatory conditions.
Yuefeng Ju, MaoJing Wang, Yang Ji, Zhihui Wang, Wenzhuo Wang, Feiyue Liu, Qing Zhao   +6 more
doaj   +1 more source

Clinical risk stratification of paediatric renal transplant recipients using C1q and C3d fixing of de novo donor-specific antibodies [PDF]

, 2017
Introduction: We have previously shown that children who developed de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) had greater decline in allograft function.
A Fearn, A Fichtner, A Loupy, A Sicard, Anthony Dorling, AR Tambur, BD Tait, C Dorje, C Dudley, C Lefaucheur, Chloe Martin, DB Jose Pinheiro, EF Reed, George Michaelides, JJ Kim, JJ Kim, Jon Jin Kim, KA Thomas, L Krischock, L Rees, LD Cornell, M Nangaku, N Lachmann, Neil J. Sebire, Nizam Mamode, O Aubert, Olivia Shaw, P Comoli, P Cravedi, R Lv, Ramnath Balasubramaniam, RC Walsh, Robert Vaughan, S Schaub, Stephen D. Marks, VR Dharnidharka   +35 more
core   +3 more sources