Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
The complement system at the embryo implantation site: friend or foe?
Frontiers in Immunology, 2012 An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla +2 more
doaj +1 more source
Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]
, 2005 Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aasa-Chapman, M.M.I. +10 more
core
Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model
Aging Cell, EarlyView.Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du +10 more
wiley +1 more source
Aging Cell, EarlyView.In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu +8 more
wiley +1 more source
Allergy, EarlyView.SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy +17 more
wiley +1 more source
Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera [PDF]
, 1972 K.B.M. Reid, Diane M. Lowe, Roy Porter
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Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis [PDF]
, 2017 Background. In systemic lupus erythematosus patients, a strong association between the occurrence of antibodies against complement C1q (anti-C1q) and lupus nephritis can be observed.
Bigler, Cornelia +5 more
core
Complement dysregulation in human tauopathies
Brain Pathology, EarlyView.Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo +3 more
wiley +1 more source
Amino acid sequence of the N-terminal forty-two amino acid residues of the C chain of subcomponent C1q of the first component of human complement [PDF]
, 1977 K.B.M. Reid
openalex +1 more source