Results 121 to 130 of about 42,931 (245)

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Long‐term remission of type B insulin resistance syndrome with immunotherapy: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT We report long‐term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55‐year‐old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high‐dose insulin and recombinant ...
Erika Egawa, Rei Karasawa, Yuka Kageyama, Kazuhiko Takaya   +3 more
wiley   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

The complement system at the embryo implantation site: friend or foe?

Frontiers in Immunology, 2012
An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla, Fleur eBossi, Francesco eTedesco   +2 more
doaj   +1 more source

Humán dendritikus sejtek működésének szabályozása komplementfehérjék és receptoraik által; exosomák jelentősége a T-sejt válasz kialakításában = Regulation of the function of dendritic cells by complement proteins and receptors; the role of exosomes in the development of T-cell response [PDF]

, 2011
A dendritikus sejtek (DC-k) érését számos stimulus indukálja, mint például a gyulladásos körülmények vagy mikrobiális termékek jelenléte. A szervezetbe kerülő antigén a komplementrendszer aktiválódása következtében opszonizált formában van jelen, ami az
Bajtay, Zsuzsa, Erdei, Anna, Isaák, Andrea   +2 more
core  

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye, Wei Gao, Jiaping Feng, Xue Li, Jianhui Li, Fengge Yang, Linqing Li, Mingsheng Zi, Xinkai Wu, Hainan Gao, Honglin Li   +10 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source