Results 181 to 190 of about 40,238 (270)

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength.

, 1985
Pak H. Poon, Martin L. Phillips, Verne N. Schumaker   +2 more
openalex   +1 more source

Complement C1q regulates LPS‐induced cytokine production in bone marrow‐derived dendritic cells [PDF]

, 2003
Masahide Yamada, Kenji Oritani, Tsuneyasu Kaisho, Jun Ishikawa, Hitoshi Yoshida, Isao Takahashi, Shinichirou Kawamoto, Naoko Ishida, Hidetoshi Ujiie, Hiroaki Masaie, Marina Botto, Yoshiaki Tomiyama, Yūji Matsuzawa   +12 more
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Activation of a complex of C1r and C1s subcomponents of human complement C1 by the third subcomponent C1q.

, 1980
T.Y. Lin, D. Fletcher
openalex   +1 more source

The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties [PDF]

, 2003
Christine Gaboriaud, Judith Juanhuix, Arnaud Gruez, Monique Lacroix, Claudine Darnault, David Pignol, Denis Verger, Juan C. Fontecilla‐Camps, Gérard J. Arlaud   +8 more
openalex   +1 more source

Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Dementia and depression are two prevalent disorders that warrant attention due to their high prevalence and contribution to the global burden of disease. Depression is a prevalent condition among the elderly population, and it has been identified as a risk factor for dementia, thus becoming an important factor for dementia prevention strategies ...
Pedro Borges de Souza, Ana Lúcia S. Rodrigues, Fernanda G. De Felice   +2 more
wiley   +1 more source

Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women. [PDF]

J Inflamm Res, 2022
Ma Y, Ding X, Shao M, Qiu Y, Li S, Cao W, Xu G.   +6 more
europepmc   +1 more source

Transcriptomic time course of skeletal muscle disuse and rehabilitation in middle‐aged adults

Physiological Reports, Volume 13, Issue 15, August 2025.
Abstract Disuse drives rapid muscle atrophy and metabolic dysfunction. This study aimed to characterize phenotypic and transcriptomic skeletal muscle changes in middle‐aged individuals during disuse and rehabilitation. Eleven healthy middle‐aged adults (6 males, 5 females; age; 57 ± 5 years) underwent 7 days of unilateral lower limb suspension (ULLS ...
Zachary D. Von Ruff, Sean P. Kilroe, Erik D. Marchant, Emily J. Arentson‐Lantz, Steven Widen, Jill Thompson, Alejandro Villasante‐Tezanos, Elena Volpi, Doug Paddon‐Jones, Blake B. Rasmussen   +9 more
wiley   +1 more source

Detection of Complement C1q B Chain Overexpression and Its Latent Molecular Mechanisms in Cervical Cancer Tissues Using Multiple Methods. [PDF]

Int J Genomics, 2022
Lin ST, Liang ZQ, Chen XY, Ye XQ, Pang YY, Luo JY, Chen JH, Dang YW, Chen G.   +8 more
europepmc   +1 more source