Results 201 to 210 of about 41,630 (234)

New insight into the autoimmunogenicity of the complement protein C1q

Molecular Immunology, 2011
C1q along with its physiological role in maintenance of homeostasis and normal function of the immune system is involved in pathological conditions associated with repetitive generation of anti-C1q autoantibodies. The time and events that cause their first appearance are still unknown.
Vishnya, Stoyanova, Svetla, Petrova, Magdalena, Tchorbadjieva, Boriana, Deliyska, Vasil, Vasilev, Ivanka, Tsacheva   +5 more
openaire   +2 more sources

Complement Activation And C1q Binding Activity In Haemodialysis

Thrombosis and Haemostasis, 1981
It has been proposed that hypoxia occurring during Haemodialysis (HD) is related to complement activation by the dialysis membrane. Consequent leucocyte aggregation may then lead to pulmonary micro-embolisation. We set out to assess complement activation during HD using a new, sensitive, assay for activation fragment C3d.Twenty patients, established on
N J, Dodd, D, Vergani, J H, Turney, V, Parsons, M J, Weston   +4 more
openaire   +2 more sources

Structure-function studies of the receptors for complement C1q

Biochemical Society Transactions, 2002
C1q is an essential component of the phylo-genetically ancient innate complement (C) system and is crucial to our natural ability to ward off infection and clear toxic cell debris (e.g. amyloid fibrils, apoptotic cells). Several candidate C1q receptors [C1q receptor for phagocytosis enhancement (C1qRp), complement receptor (CR) 1, calreticulin (CRT ...
E, McGreal, P, Gasque
openaire   +2 more sources

Roles of Complement C1q in Pneumococcus-Host Interactions

Critical Reviews in Immunology, 2015
The fight between a human host and a bacterial pathogen is highly complicated; each party tries to outshine the other in the race for survival. In humans, the innate immune system--in particular the complement system--functions as the first line of defence against invading pathogens.
Vaibhav, Agarwal, Anna M, Blom
openaire   +2 more sources

Interaction of plasma fibronectin with gelatin and complement C1q

Molecular Immunology, 1983
A variety of techniques have been used to examine the interaction of human plasma fibronectin (Fn) with complement C1q in comparison to that with gelatin in phosphate buffered saline at pH 7.4. The precipitation of 3H-Fn by polyethylene glycol (PEG) was shifted to much lower concentrations of the polymer by addition of gelatin, and to a lesser extent ...
K C, Ingham, S A, Brew, S I, Miekka
openaire   +2 more sources

Adsorption of Complement Proteins C3 and C1q

Journal of Colloid and Interface Science, 1996
Abstract Surface localization plays a key but ill defined role in activation of the serum complement system with or without related “opsonic” proteins. The adsorption of key complement components C3 and C1q and various opsonins, e.g., IgG, were therefore studied on different surfaces usingin situellipsometry.
Martin Malmsten, Bo Lassen, James M. Van Alstine, Ulf R. Nilsson   +3 more
openaire   +1 more source

C1q: the perfect complement for a synaptic feast?

Nature Reviews Neuroscience, 2008
The efficient and selective removal of apoptotic cells is an important feature of tissue development, homeostasis and pathology. In the nervous system, synapses and distal axons are selectively eliminated as part of the remodelling that underpins development and pathology, through a process that has some features in common with apoptotic cell removal ...
Perry, V. Hugh, O'connor, Vincent
openaire   +2 more sources

The conformation of subcomponent C1q of the first component of human complement

Nature, 1980
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Gilmour, S., Randall, Jt, Willan, Kj, Dwek, Ra, Torbet, J.   +4 more
openaire   +3 more sources

Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia

Experimental Neurology, 2000
Recent studies showing that microglia internalize the amyloid beta-peptide (Abeta) suggest that these cells have the potential for clearing Abeta deposits in Alzheimer's disease, and mechanisms that regulate the removal of Abeta may therefore be of clinical interest.
S D, Webster, A J, Yang, L, Margol, W, Garzon-Rodriguez, C G, Glabe, A J, Tenner   +5 more
openaire   +2 more sources

Adiponectin binds C1q and activates the classical pathway of complement

Biochemical and Biophysical Research Communications, 2008
The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++)
Philip W, Peake, Yvonne, Shen, Alexandra, Walther, John A, Charlesworth   +3 more
openaire   +2 more sources