Results 231 to 240 of about 42,931 (245)
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C1q component of complement binds to fibrinogen and fibrin
Biochemistry, 1988The interaction of complement component C1q with fibrinogen and fibrin was studied by using a solid-phase direct binding assay. Scatchard analysis of radioiodinated fibrinogen binding to C1q indicated at least two high-affinity binding constants (Kd) calculated as 8.5 and 120 nM. In contrast, binding of radioiodinated fibrin to C1q showed only a single
R A, Entwistle, L T, Furcht
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Differential chemokine response of fibroblast subtypes to complement C1q
Journal of Periodontal Research, 2006Background and Objective: The pathogenesis of periodontitis includes an inappropriate activation of the classical complement cascade (C′) with accumulation of inflammatory C′ products in fluids and tissues. Our hypothesis is that in vivo the C′ product, C1q, may act as a regulatory component of the innate immune response of distinct matrix fibroblasts
S, Verardi +3 more
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Binding of complement component C1q by rat adipocyte membranes
Molecular Immunology, 1985Human C1q was found to bind to rat adipocyte membranes with an affinity comparable to that for aggregated immunoglobulin. The binding was ionic strength dependent, and modification of arginyl and histidyl residues in C1q abrogated its binding activity.
A, Comis, S B, Easterbrook-Smith
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Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis
Molecular Immunology, 2008Autoantibodies against complement C1q (anti-C1q) strongly correlate with the occurrence of severe lupus nephritis. Recent data suggest that anti-C1q might also correlate with more severe forms of acute post-streptococcal glomerulonephritis (APSGN). Therefore, we prospectively investigated the role of anti-C1q in 50 children with newly diagnosed APSGN ...
Kozyro, I. +5 more
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Structure-function studies of the receptors for complement C1q
Biochemical Society Transactions, 2002C1q is an essential component of the phylo-genetically ancient innate complement (C) system and is crucial to our natural ability to ward off infection and clear toxic cell debris (e.g. amyloid fibrils, apoptotic cells). Several candidate C1q receptors [C1q receptor for phagocytosis enhancement (C1qRp), complement receptor (CR) 1, calreticulin (CRT ...
E, McGreal, P, Gasque
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Complement protein C1q induces maturation of human dendritic cells
Molecular Immunology, 2007Maturation of dendritic cells (DCs) is known to be induced by several stimuli, including microbial products, inflammatory cytokines and immobilized IgG, as demonstrated recently. Since immune complexes formed in vivo also contain C1q, moreover apoptotic cells and several pathogens fix C1q in the absence of antibodies, we undertook to investigate ...
Cosmor, E +6 more
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Interaction of plasma fibronectin with gelatin and complement C1q
Molecular Immunology, 1983A variety of techniques have been used to examine the interaction of human plasma fibronectin (Fn) with complement C1q in comparison to that with gelatin in phosphate buffered saline at pH 7.4. The precipitation of 3H-Fn by polyethylene glycol (PEG) was shifted to much lower concentrations of the polymer by addition of gelatin, and to a lesser extent ...
K C, Ingham, S A, Brew, S I, Miekka
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Activation of Mammalian Complement by Chicken C1q
1983Activation of chicken complement by the classical pathway is still debatable. Both positive and negative evidence of antibody dependent lysis has been reported. The components from C3 to C9 function since activation via the alternative pathway will lyse mammalian erythrocytes in the absence of Ig.
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Biochemical Specificity of Human Complement Component C1q
1983The serum complement system has an important role in host defense and haemostasis, and inflammatory processes1. It consists of 9 components, 2 factors and 9 regulatory processes2,3. With the exception of factor D, the complement proteases circulate in vivo as zymogens which are activated to a system of interacting transiently active proteases by ...
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