Results 211 to 220 of about 41,630 (234)

Differential chemokine response of fibroblast subtypes to complement C1q

Journal of Periodontal Research, 2006
Background and Objective:  The pathogenesis of periodontitis includes an inappropriate activation of the classical complement cascade (C′) with accumulation of inflammatory C′ products in fluids and tissues. Our hypothesis is that in vivo the C′ product, C1q, may act as a regulatory component of the innate immune response of distinct matrix fibroblasts
S, Verardi, R C, Page, W F, Ammons, S, Bordin   +3 more
openaire   +2 more sources

Binding of complement component C1q by rat adipocyte membranes

Molecular Immunology, 1985
Human C1q was found to bind to rat adipocyte membranes with an affinity comparable to that for aggregated immunoglobulin. The binding was ionic strength dependent, and modification of arginyl and histidyl residues in C1q abrogated its binding activity.
A, Comis, S B, Easterbrook-Smith
openaire   +2 more sources

Complement C1q Does Not Bind Monomeric β-Amyloid

Experimental Neurology, 1994
The tendency of both labeled and unlabeled beta-amyloid to bind in solution to C1q, the recognition species in the complement cascade, was examined using both hydrodynamic and spectroscopic methods. Potential binding interactions were evaluated using a purified synthetic beta-amyloid 1-40 sequence, alone, and selectively labeled at the amino terminus ...
S W, Snyder, G T, Wang, L, Barrett, U S, Ladror, D, Casuto, C M, Lee, G A, Krafft, R B, Holzman, T F, Holzman   +8 more
openaire   +2 more sources

Activation of Mammalian Complement by Chicken C1q

1983
Activation of chicken complement by the classical pathway is still debatable. Both positive and negative evidence of antibody dependent lysis has been reported. The components from C3 to C9 function since activation via the alternative pathway will lyse mammalian erythrocytes in the absence of Ig.
openaire   +1 more source

The C1q complement family of synaptic organizers: not just complementary

Current Opinion in Neurobiology, 2017
Molecules that regulate formation, differentiation, and maintenance of synapses are called synaptic organizers. Recently, various 'C1q family' proteins have been shown to be released from neurons, and serve as a new class of synaptic organizers. Cbln1 and C1ql1 proteins regulate the formation and maintenance of parallel fiber-Purkinje cell and climbing
openaire   +2 more sources

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Immunity, 2023
Zhihao Lin, Li Zhong
exaly  

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Douwe J Dijkstra, Leoni Abendstein, Cynthia S M Krämer   +2 more
exaly  

Complement component 1Q (C1Q)

Science-Business eXchange, 2010
openaire   +1 more source

Increased serum levels of complement C1q in major depressive disorder

Journal of Psychosomatic Research, 2020
Yan Li
exaly  

Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction

Developmental and Comparative Immunology, 2020
Fangfang Yan, Enxu Zhou, Along Gao
exaly