Results 91 to 100 of about 97,543 (311)

Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the correlation between complement level of C3， other risk factors and cognitive dysfunction in patients with end-stage renal disease （ESRD）.MethodsFrom July 2019 to July 2021， medical records and laboratory examinations were ...
Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui   +5 more
doaj  

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Cutaneous Vasculitis and Digital Ischaemia Caused by Heterozygous Gain-of-Function Mutation in C3

Frontiers in Immunology, 2018
It is now increasingly recognized that some monogenic autoinflammatory diseases and immunodeficiencies cause vasculitis, although genetic causes of vasculitis are extremely rare.
Ebun Omoyinmi, Ebun Omoyinmi, Iman Mohamoud, Kimberly Gilmour, Paul A. Brogan, Paul A. Brogan, Despina Eleftheriou, Despina Eleftheriou, Despina Eleftheriou   +8 more
doaj   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

Advanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang, Xiaoxue Ruan, Xudong Hang, Ding Heng, Chang Cai, Liping Zeng, Guoxin Zhang, Lu Zhou, Hongkai Bi, Liang Zhang   +9 more
wiley   +1 more source

Complement C3

, 2012
Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (~177 kDa) and C3a (~9 kDa) is a crucial step in the complement activation cascade, which can be ...
Dinasarapu, Ashok Reddy, Chandrasekhar, Anjana, Sahu, Arvind, Subramaniam, Shankar   +3 more
openaire   +1 more source

Serum Albumin and C3 Complement Levels in Endometriosis

Journal of the College of Physicians and Surgeons Pakistan, 2019
To compare the efficacy of albumin and C3 complement as serum marker for the early diagnosis of endometriosis in women of reproductive age.Cross-sectional comparative study.Biochemistry Department, Islamic International Medical College, Rawalpindi, in collaboration with the Gynecology and Obstetrics Department, Pakistan Railways Hospital, Rawalpindi ...
Saira Jahan, Abdul Khaliq Naveed, Muhammad Afzal, Aisha Hasan, Amena Rahim, Saddaf Ayub   +5 more
openaire   +2 more sources

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Frontiers in Immunology, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham   +8 more
doaj   +1 more source