Results 91 to 100 of about 976,787 (206)

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

PLoS Pathogens, 2017
The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bacteria
Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan   +6 more
doaj   +1 more source

Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment

Kidney International Reports, 2019
Introduction: Therapeutic agents that target complement are increasingly available for glomerular diseases. However, the mechanisms linking glomerular complement deposition with inflammation and damage are incompletely understood.
Nicholas R. Medjeral-Thomas, Hilary Moffitt, Hannah J. Lomax-Browne, Nicholas Constantinou, Tom Cairns, H. Terence Cook, Matthew C. Pickering   +6 more
doaj   +1 more source

Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels.

PLoS ONE, 2014
Age-related macular degeneration (AMD) is a common condition that leads to severe vision loss and dysregulation of the complement system is thought to be associated with the disease.
Tina Ristau, Constantin Paun, Lebriz Ersoy, Moritz Hahn, Yara Lechanteur, Carel Hoyng, Eiko K de Jong, Mohamed R Daha, Bernd Kirchhof, Anneke I den Hollander, Sascha Fauser   +10 more
doaj   +1 more source

Complement (C3), nutrition, and infection.

Bulletin of the World Health Organization, 1979
Complement (C(3)) was determined and related to various parameters of nutritional status and past infectious disease experience in a group of 53 rural preschool children in North India. Mean complement level was 25% lower than in an age-matched European reference population.
A A, Kielmann, L M, Curcio
openaire   +1 more source

Complement 3 (C3) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1

Neuroscience Bulletin, 2021
Guang-Tong Jiang, Lin Shao, Shuo Kong, Meng-liu Zeng, Jing-Jing Cheng, Taoxiang Chen, Song Han, Jun Yin, Wanhong Liu, Xiao-hua He, Yu-min Liu, Lanzi Gongga, Bi-wen Peng   +12 more
semanticscholar   +1 more source

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

eLife
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathogens ...
Alexander D Cook, Mark Carrington, Matthew K Higgins   +2 more
doaj   +1 more source

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Science Translational Medicine, 2017
Qiaoqiao Shi, Saba J Chowdhury, Rong Ma, Kevin X. Le, Soyon Hong, B. Caldarone, B. Stevens, C. Lemere   +7 more
semanticscholar   +1 more source

Complement 3 (C3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Alternative c3 complement system

Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
García-Arguinzonis, Maisa||, Diaz-Riera, Elisa||, Peña, Esther||, Escate, Rafael||, Juan-Babot, Oriol||, Mata, Pedro, Badimon, Lina||, Padró, Teresa||   +7 more
openaire   +1 more source