Results 101 to 110 of about 268,987 (334)

TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement [PDF]

, 2014
Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of ...
Bialas, Allison R., Stevens, Beth
core   +1 more source

Hybrid Microdiscs for Magnetically Induced Non‐Cytotoxic Thermal Actuation and Programmable Biomolecule Delivery

Advanced Functional Materials, EarlyView.
Hybrid magnetic microdiscs with customizable size and composition are engineered through refined photolithography and LbL assembly. Embedded Fe3O4 nanoparticles enable localized, non‐cytotoxic heating, while protein cargos can be incorporated in tunable quantities.
Daniela Iglesias‐Rojas, Danny Villanueva, Jon Mentxaka‐Salgado, Nerea Lete, Ane Olazagoitia‐Garmendia, Eduardo Fernández, Iñaki Orue, Alfredo García‐Arribas, Maria Luisa Fdez‐Gubieda, Ainara Castellanos‐Rubio, Robert Morel, Bernard Dieny, Maite Insausti, Idoia Castellanos‐Rubio   +13 more
wiley   +1 more source

Cutaneous Vasculitis and Digital Ischaemia Caused by Heterozygous Gain-of-Function Mutation in C3

Frontiers in Immunology, 2018
It is now increasingly recognized that some monogenic autoinflammatory diseases and immunodeficiencies cause vasculitis, although genetic causes of vasculitis are extremely rare.
Ebun Omoyinmi, Ebun Omoyinmi, Iman Mohamoud, Kimberly Gilmour, Paul A. Brogan, Paul A. Brogan, Despina Eleftheriou, Despina Eleftheriou, Despina Eleftheriou   +8 more
doaj   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, EarlyView.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source

Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the correlation between complement level of C3， other risk factors and cognitive dysfunction in patients with end-stage renal disease （ESRD）.MethodsFrom July 2019 to July 2021， medical records and laboratory examinations were ...
Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui   +5 more
doaj  

670-nm light treatment reduces complement propagation following retinal degeneration

, 2016
AIM Complement activation is associated with the pathogenesis of age-related macular degeneration (AMD). We aimed to investigate whether 670-nm light treatment reduces the propagation of complement in a light-induced model of atrophic AMD.
Albarracin, Rizalyn, Natoli, Riccardo, Provis, Jan, Rutar, Matt, Valter, Krisztina   +4 more
core   +1 more source

Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces

Advanced Healthcare Materials, EarlyView.
Aerosol jet printing enables rapid, customizable fabrication of flexible, fully gold multi‐electrode arrays (MEAs) for organotypic bioelectronic interfaces. The printed MEAs exhibit stable electrochemical performance, cytocompatibility, and functionality in recording and stimulation, including integration with 3D‐printed constructs.
Ernest Cheah, Xinchao Gao, Wei Qi Jaw, Guo Liang Goh, Jia Min Lee, Chongquan Huang, Sing Yian Chew, Wai Yee Yeong   +7 more
wiley   +1 more source

A new role for complement C3: regulation of antigen processing through an inhibitory activity. [PDF]

, 2008
International audienceIncreasing evidence underlines the involvement of complement component C3 in the establishment of acquired immunity which appears to play a complex role and to act at different levels.
Al Salihi, Armstrong, Bottger, Burster, Carroll, Cherukuri, Christian L. Villiers, Cretin, Delamarre, Delamarre, Dempsey, Dodds, Einstein, Fearon, Fischer, François Cretin, Hawlisch, Hewitt, Hsieh, Jacquier-Sarlin, Janssen, Law, Lopez-Rodriguez, Manoury, Marie-Bernadette Villiers, Morgan, Nicole Lefebvre, Ochs, Patrice N. Marche, Peng, Pepys, Perrin-Cocon, Polla, Puri, Rey-Millet, Rey-Millet, Ruckrich, Salacinski, Santoro, Savina, Schulman, Serra, Shi, Sim, Sundström, Tack, Takafuji, Takahashi, Vidard, Villiers, Villiers, Villiers, Villiers, Villiers, Villiers, Villiers, Wagner, Wagner, Walport, Weiss, Zhou   +60 more
core   +4 more sources

The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles

Advanced Healthcare Materials, EarlyView.
Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu, Tianchang He, Chunjie Miao, Xinyang Shi, Yuanyuan Niu, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Frontiers in Immunology, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham   +8 more
doaj   +1 more source