Results 121 to 130 of about 74,672 (291)

O‐GalNAc Glycosylation Activates MBL‐Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Advanced Science, EarlyView.
Upregulated glycosyltransferase GALNT9 in neuroendocrine (NE) carcinomas increases O‐GalNAc glycosylation on cell membrane proteins, particularly Annexin‐A2 (ANXA2). Elevated O‐GalNAc glycan induces the binding of NE cancer cells to mannose binding lectin 2 (MBL2), activating the MBL‐MBL associated serine protease (MBL‐MASP) complement pathway in the ...
Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi‐Fai Ng, Jiahua Pan, Wei Xue, Wei‐Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu   +24 more
wiley   +1 more source

Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells

, 1978
Michael K. Pangburn, Hans J. Müller‐Eberhard   +1 more
openalex   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Chemical evidence for common genetic ancestry of complement components C3 and C5.

, 1977
H N Fernandez, T E Huglij
openalex   +1 more source

Characterization of the initial C3 convertase of the alternative pathway of human complement. [PDF]

, 1984
Zvi Fishelson, Michael K. Pangburn, Hans J. Müller‐Eberhard   +2 more
openalex   +1 more source

Unveiling the Fundamental Principles of Reconfigurable Resistance States in Silver/Poly(Ethylene Glycol) Nanofluids

Advanced Science, EarlyView.
The electrophoretic reorganization of Ag nanoparticles within a poly(ethylene glycol) leads to the formation of conductive bridges with reconfigurable resistance states. Diverse conduction characteristics of the bridge range between ohmic conduction, nonlinear tunneling, or space charge‐limited conduction, and high resistance states.
Daniil Nikitin, Kateryna Biliak, Mariia Protsak, Blessing Adejube, Suren Ali‐Ogly, Kateřina Škorvanková, Veronika Červenková, Ronaldo Katuta, Marco Tosca, Jan Hanuš, Zulfiya Černochová, Peter Černoch, Petr Štěpánek, Oleksandr Boiko, Paulina Szymoniak, Andreas Schönhals, Franz Faupel, Hynek Biederman, Alexander Vahl, Andrei Choukourov   +19 more
wiley   +1 more source

Monoclonal antibodies against complement 3 neoantigens for detection of immune complexes and complement activation. Relationship between immune complex levels, state of C3, and numbers of receptors for C3b. [PDF]

, 1985
M. Teresa Aguado, John D. Lambris, George C. Tsokos, Reinhard Bürger, D Bitter-Suermann, John D. Tamerius, Frank J. Dixon, Argyrios N. Theofilopoulos   +7 more
openalex   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Homeostasis of DNA Hemi‐Methylation in Arabidopsis through Methylation Maintenance, DNA Replication, and Nucleosome Positioning Mechanisms

Advanced Science, EarlyView.
In Arabidopsis, the homeostasis of full‐ and hemi‐methylation is mainly regulated by maintenance methylation. The maintenance methylation at hemi‐methylated dyads is highly efficient but the efficiency differs at euchromatic or heterochromatic regions. Nucleosomes impair the hemi‐ to full‐methylation transition. Lagged methylation maintenance after DNA
Hengye Chen, Chenhuan Xu
wiley   +1 more source

Complement C3 Reduces Apoptosis via Interaction with the Intrinsic Apoptotic Pathway. [PDF]

Cells, 2023
Fang Z, Lee H, Liu J, Wong KA, Brown LM, Li X, Xiaoli AM, Yang F, Zhang M.   +8 more
europepmc   +1 more source