Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Assessment of humoral immunity in workers occupationally exposed to low levels of ionizing radiation [PDF]
Background: The aim of this study was investigating the effect of low levels of ionizing radiation on immunoglobulin, complement levels in radiology workers occupationally exposed to ionizing radiation.
تبرائی, یاسر +3 more
core +1 more source
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Acute induction of interleukin‐6 and biphasic changes of serum complement C3 by carrageenan in mice [PDF]
, 1998 Kazuhiro Tateda +2 more
openalex +1 more source
Advanced Science, EarlyView.Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You +12 more
wiley +1 more source
A komplementrendszer immunfunkciókat szabályozó szerepe fiziológiás és kóros folyamatok során = Immunoregulatory role of complement under physiological and pathological conditions [PDF]
, 2012 A komplementrendszer immunvédekezésünk szerves része. A legnagyobb mennyiségben előforduló komponens, a C3 szerepe igen változatos; a patogének eliminálásától az immunválasz szabályozásáig terjed.
Bajtay, Zsuzsa +6 more
core
Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum [PDF]
, 2013 Elena Del Tordello +4 more
openalex +1 more source
Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy
Advanced Science, EarlyView.This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao +6 more
wiley +1 more source
Mutants of complement component C3 cleaved by the C4-specific C1-s protease. [PDF]
, 1992 Patricia Mathias +4 more
openalex +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, EarlyView.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source