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Seminars in Immunology, 2022
C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G is driven by uncontrolled overactivation of the alternative complement pathway, which is mainly of acquired origin.
Marie-Sophie, Meuleman +2 more
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C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G is driven by uncontrolled overactivation of the alternative complement pathway, which is mainly of acquired origin.
Marie-Sophie, Meuleman +2 more
openaire +2 more sources
Complement inhibition in C3 glomerulopathy
Seminars in Immunology, 2016C3 glomerulopathy (C3G) describes a spectrum of glomerular diseases defined by shared renal biopsy pathology: a predominance of C3 deposition on immunofluorescence with electron microscopy permitting disease sub-classification. Complement dysregulation underlies the observed pathology, a causal relationship that is supported by well described studies ...
Carla M, Nester, Richard J H, Smith
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Complement C3 proteins in psoriasis
British Journal of Dermatology, 1989A new polymorphism of the complement factor C3 in human plasma was demonstrated by isotachophoresis in agarose gels followed by immunodetection with rabbit anti-human C3c and C3d immunoglobulins. Four bands were detected in the immunoprint of freshly drawn EDTA-plasma, which were C3s1, C3s2, C3f1 and C3f2. At least four additional C3 components in Mg2+
F, Acevedo, H, Hammar
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Complement C3 in Bernese Mountain dogs
Veterinary Clinical Pathology, 2010Background:Previous research suggests that low serum concentrations of the third component of complement (C3) are associated with both the susceptibility to infectious agents such asBorrelia burgdorferiand the development of glomerular disease. We hypothesized that low levels of C3 are associated with the coincident occurrence ofB. burgdorferiinfection
Gerber, Bernhard +4 more
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Inherited complement C3 deficiency: A defect in C3 secretion
European Journal of Immunology, 1994AbstractThe molecular basis of inherited complement C3 deficiency in a 20‐year‐old newly diagnosed male patient was studied. Using an enzyme‐linked immunosorbent assay, the patient's C3 serum level was found to be approximately 7 μg/ml, which is less than 1 % of normal.
Y, Katz +4 more
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Complement C3 receptors: Structure and function
Molecular Immunology, 1984Significant progress has been made during the past few years toward elucidating the structure and function of various C3 receptors. Better understanding of the biochemical basis of the immune adherence phenomenon has been achieved. The availability of polyclonal and monoclonal antibodies to C3 receptors allowed more accurate studies of the cellular ...
M A, Arnaout, H R, Colten
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Complement C3 isoforms in Austrelaps superbus
Toxicon, 2008Complement C3 plays a pivotal role in both classical and alternate pathways. Lower organisms (urochordates and fishes) have multiple isoforms whereas higher organisms have a single C3 gene. In cobras, a closely related protein cobra venom factor (CVF) is expressed in their venom gland.
Syed, Rehana, R Manjunatha, Kini
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Fish and Shellfish Immunology, 2019
Aeromonas hydrophila is a pathogen that causes high mortality in the grass carp. The complement system, as a frontline defence of innate immunity, plays an important role in the immune response against pathogens.
Dan-Dan Chen +3 more
semanticscholar +1 more source
Aeromonas hydrophila is a pathogen that causes high mortality in the grass carp. The complement system, as a frontline defence of innate immunity, plays an important role in the immune response against pathogens.
Dan-Dan Chen +3 more
semanticscholar +1 more source
Alzheimer's & Dementia, 2018
We tested the hypothesis that low plasma complement C3 is observationally and genetically associated with high risk of Alzheimer's disease (AD).
K. Rasmussen +3 more
semanticscholar +1 more source
We tested the hypothesis that low plasma complement C3 is observationally and genetically associated with high risk of Alzheimer's disease (AD).
K. Rasmussen +3 more
semanticscholar +1 more source