Results 201 to 210 of about 862,879 (325)

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides

Angewandte Chemie, EarlyView.
Splice‐switching oligonucleotides are used to treat severe genetic conditions including Duchenne Muscular Dystrophy, but new chemistries are urgently required to improve their efficacy. In this work locked nucleic acid (LNA) is coupled to different charge neutral DNA backbones which are studied by structural, thermodynamic, and biological methods.
Alice Kennett, Lillian Lie, Martin Flerin, Belma Zengin Kurt, Ysobel R. Baker, Alyssa C. Hill, Abinaya Ramesh, Matthew J.A. Wood, Debashis Dhara, Afaf H. El‐Sagheer, Fernanda Duarte, Tom Brown   +11 more
wiley   +2 more sources

Targeting complement C3 with Tanshinone I decreases microglia-mediated synaptic engulfment to exert antidepressant effects. [PDF]

Theranostics
Lai H, Fan P, Zhang P, Zhang M, Li X, Kuang B, Zhou R, Wang W, Jiang H, Wang Z, Chen N.   +10 more
europepmc   +1 more source

Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus. [PDF]

Front Mol Neurosci, 2023
Schartz ND, Aroor A, Li Y, Pinzón-Hoyos N, Brewster AL.   +4 more
europepmc   +1 more source

Anti-KCA-3, a monoclonal antibody reactive with a rat complement C3 receptor, distinguishes Kupffer cells from other macrophages. [PDF]

, 1993
Masafumi Maruiwa, Atsushi Mizoguchi, G.J. Russell, Navneet Narula, M Stronska, Emiko Mizoguchi, Hamid Rabb, M. Amin Arnaout, A K Bhan   +8 more
openalex   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

Driving Multi‐Step Regioselectivity in On‐Surface Polymer Synthesis by Molecular Coverage

Angewandte Chemie, EarlyView.
Regioselective polymerization of dicyclopentaanthracene on Au(111) can be controlled by tuning molecular coverage. Low coverage yields 1D polymers, medium coverage produces quasi‐1D staircase polymers, and higher coverage drives 2D porous networks.
Kalyan Biswas, Alba García‐Frutos, Berta Álvarez, Marco Lozano, Ana Barragán, Jesús Janeiro, Jesús Bello‐García, Diego Soler‐Polo, Koen Lauwaet, José M. Gallego, Dolores Pérez, Rodolfo Miranda, José I. Urgel, Pavel Jelínek, Diego Peña, David Écija   +15 more
wiley   +2 more sources

The role of complement C3 deposition in ANCA-associated glomerulonephritis: a registry-based study of clinical, histopathological, and prognostic insights. [PDF]

BMC Nephrol
Uzun S, Gok Oguz E, Yıldız A, Derici U, Cankaya E, Sahin G, Tatar E, Şahin G, Dinçer MT, Eren N, Turgutalp K, Baştürk T, Öğütmen MB, Tanrısev M, Kutlay S, Yilmaz M, Gürsu M, Yılmaz Z, Toprak Z, Tunca O, Karakan Ş, Ük E, Dursun B, İslam M, Torun D, Gul CB, Kaya B, Altun B, Çelik A, Şahin İ, Yadigar S, Gibyeli Genek D, Ayli MD, Güllülü Boz SE, Akcay OF, Keleş M, Öztürk S.   +36 more
europepmc   +1 more source

The role of complement C3 in the outcome of regional myocardial infarction. [PDF]

Biochem Biophys Rep, 2023
Fang Z, Li X, Liu J, Lee H, Salciccioli L, Lazar J, Zhang M.   +6 more
europepmc   +1 more source

Forecasting Research Trends Using Knowledge Graphs and Large Language Models

Advanced Intelligent Systems, EarlyView.
When research trends can be anticipated, academia and industry are able to allocate limited resources more effectively and accelerate innovation. By constructing knowledge graphs using large language models, this study analyzes the time evolution of nuclear materials research concepts and suggests a data‐driven approach of forecasting research trends ...
Maciej Tomczak, Yang Jeong Park, Chia‐Wei Hsu, Payden Brown, Dario Massa, Piotr Sankowski, Ju Li, Stefanos Papanikolaou   +7 more
wiley   +1 more source

EDA Complex‐Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP

Angewandte Chemie, EarlyView.
In this work, we report a novel light‐mediated desaturation strategy enabled by electron donor–acceptor complex formation. DFT and mechanistic studies reveal that the reaction proceeds via single‐electron transfer, hydrogen atom transfer, and base‐mediated deprotonation sequentially with pyridinium salt serving dually as oxidant and base, and ...
Rakesh Maiti, Robin Cauwenbergh, Aritra Nath, Ana B. R. Guimarães, Yuman Qin, Feliu Maseras, Shoubhik Das   +6 more
wiley   +2 more sources