Results 361 to 370 of about 1,025,521 (374)

The Emerging Role of Complement C3 as A Biomarker of Insulin Resistance and Cardiometabolic Diseases: Preclinical and Clinical Evidence.

Reviews on recent clinical trials, 2018
BACKGROUND An intricate network of reciprocal interactions between adipose tissue and immune system have been largely demonstrated, leading to the well-accepted concept of insulin resistance as a low grade inflammatory state and, conversely, chronic high-
F. Ursini, L. Abenavoli
semanticscholar   +1 more source

Engineering of human complement component C3 for catalytic inhibition of complement

Immunology Letters, 2005
As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Reinhard Bredehorst, Johanna Kölln, Edzard Spillner   +2 more
openaire   +3 more sources

The role of complement factor C3 in lipid metabolism

Molecular Immunology, 2015
Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism.
Andreea Barbu, Osama A. Hamad, Lars Lind, Kristina N. Ekdahl, Bo Nilsson   +4 more
openaire   +3 more sources

Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans

The Journal of Immunology, 1996
Abstract The majority of complement protein C3 is synthesized by the liver, but many other cell types produce small amounts of functionally active C3. The overall contribution of such extrahepatic C3 production to the total circulating C3 level is unknown.
M A, Naughton, M, Botto, M J, Carter, G J, Alexander, J M, Goldman, M J, Walport   +5 more
openaire   +2 more sources

Adsorption of Complement Proteins C3 and C1q

Journal of Colloid and Interface Science, 1996
Abstract Surface localization plays a key but ill defined role in activation of the serum complement system with or without related “opsonic” proteins. The adsorption of key complement components C3 and C1q and various opsonins, e.g., IgG, were therefore studied on different surfaces usingin situellipsometry.
Martin Malmsten, James M. Van Alstine, Ulf R. Nilsson, Bo Lassen   +3 more
openaire   +2 more sources

Intracerebral hemorrhage in complement C3-deficient mice

2006
The complement cascade is activated and contributes to brain damage after intracerebral hemorrhage (ICH). The present study investigated ICH-induced brain damage in complement C3-deficient mice. This study was divided into 2 parts. Male C3-deficient and C3-sufficient mice received an infusion of 30-microl autologous whole blood into the right basal ...
Shuxu Yang, Ya Hua, Julian T. Hoff, Takehiro Nakamura, G. Xi, John G. Younger, Richard F. Keep   +6 more
openaire   +3 more sources

[74] Third component of human complement: C3

1990
Publisher Summary The third component of human complement (C3) is of great importance because it provides a subunit for three different enzymes in the complement-activation cascade and is the major opsonic protein of the serum complement system. The opsonic function of C3 is because of its ability to attach covalently to the target of complement ...
openaire   +3 more sources

Evolution of “C3 family” complement components

Developmental & Comparative Immunology, 1981
Abstract N-terminal amino acid sequences reported for human C3a and C5a anaphylatoxins and C4 α chain were compared with one another and also with 18 sequences of β 2 -microglobulins and immunoglobulin C and V domains. Moore and Goodman (1977)’s alignment statistic demonstrated that these polypeptides are homologous and therefore must have evolved ...
openaire   +2 more sources

Complement C3: A molecular mosaic of binding sites

Molecular Immunology, 1991
Many of the biological activities of the complement system are mediated by C3, the third complement component, and its proteolytic fragments. At the same time, several of the molecules which regulate complement activation target their action at the C3 molecule.
openaire   +3 more sources

Complement Components C3 and C4

2008
I stayed in the Immunochemistry Unit from 1981 to 2002. It all started with an incident that happened in Hong Kong in 1980. I was working in the Department of Genetics, Washington University School of Medicine, with Paul Levine, who was my PhD thesis supervisor at Harvard.
openaire   +2 more sources