Results 1 to 10 of about 13,327 (134)

The Complement C3a and C3a Receptor Pathway in Kidney Diseases [PDF]

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Shuang Gao, Shuang Gao, Shuang Gao, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +12 more
doaj   +5 more sources

Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α [PDF]

Journal of Neuroinflammation, 2022
Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong, Duancheng Guo, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang   +9 more
doaj   +4 more sources

The association between serum complement C3a and severity in patients with community-acquired pneumonia [PDF]

Frontiers in Immunology, 2023
BackgroundA few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure.
Zheng Xu, Zheng Xu, Zheng Xu, Xue-Feng Hou, Chun-Mei Feng, Ling Zheng, De-Xiang Xu, Hui Zhao, Hui Zhao, Lin Fu, Lin Fu, Lin Fu   +11 more
doaj   +2 more sources

Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish [PDF]

Frontiers in Immunology, 2022
The complement system is an important part of the immune system of teleost fish. Besides, teleost B cells possess both phagocytic activity and adaptive humoral immune function, unlike mammalian B1 cells with phagocytic activity and B2 cells specific to ...
Zi-You Ma, Zi-You Ma, Zi-You Ma, Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Chang-Song Wu, Chang-Song Wu, Ya-Zhen Hu, Ya-Zhen Hu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +19 more
doaj   +2 more sources

Brief report on the relation between complement C3a and anti dsDNA antibody in systemic lupus erythematosus [PDF]

Scientific Reports, 2022
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of a diverse array of autoantibodies and the dysfunctional activation of the complement system.
Yao-Hua Cai, Jun Deng, Zhao-Lin Chen, Heng Mei, Liang Tang, Shan-Shan Luo, Yu Hu   +6 more
doaj   +2 more sources

Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage. [PDF]

Front Neurosci, 2022
Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration. However, the mechanism of complement signaling in retinal degeneration needs to be further studied.
Wang S, Du L, Yuan S, Peng GH.
europepmc   +4 more sources

Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma [PDF]

Journal of Translational Medicine
Background Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that the complement C3a activates osteoclasts to participate in the pathogenesis of MBD; however, its mechanism of action is diverse
Fengjuan Jiang, Yunhe Zhang, Fengping Peng, Hui Liu, Kai Ding, Panpan Cao, Xiaohan Liu, Lijuan Li, Zhaoyun Liu, Rong Fu   +9 more
doaj   +2 more sources

Complement C3a/C3aR inhibition alleviates the formation of aortic aneurysm in Marfan syndrome mice [PDF]

BMC Cardiovascular Disorders
Mutations in fibrillin 1 (FBN1) is the main cause of Marfan syndrome (MFS) with thoracic aortic aneurysm (TAA) as the main complication. Activation of the complement system plays a key role in the formation of thoracic and abdominal aortic aneurysms ...
Fan Zhang, Kexin Yao, Yan Liu, Mei Zhou, Yanhong Zhang, Shiyao Hong, Jian Wu, Congcong Zhang   +7 more
doaj   +2 more sources

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2021
Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet ...
Emily K Kleczko, Raphael A Nemenoff, Michael William Knitz   +2 more
doaj   +2 more sources

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy.

J Am Soc Nephrol, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Gao S, Cui Z, Zhao MH.
europepmc   +3 more sources