Results 1 to 10 of about 12,526 (42)

Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke [PDF]

, 2012
The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
A Kuge, AF Ducruet, Andrew F. Ducruet, B Winter, Brad E. Zacharia, C Atkinson, E. Sander Connolly, ES Connolly Jr, J Mocco, J Mocco, JL Saver, JM Encinas, Justin W. Gorski, K Jin, LM Proctor, M Moriyama, MA Rynkowski, Marc L. Otten, Mason L. Yeh, MM Markiewski, P Gasque, P Mathieu, Paul R. Gigante, Paulina Sergot, Peter A. DeRosa, PF Zipfel, RA DeAngelis, Richard Y. Hwang, RS Ames, Sergey A. Sosunov, Simone Di Giovanni, SL Stevens, SM Drouin, T Ben-Hur, T Wang, T Yamashita, TV Arumugam, V Bouet, VS Ten, WC Jean, Y Hua, Y Kimura, Y Rahpeymai, Y Sun, YR Bogestal, Zachary L. Hickman   +45 more
core   +12 more sources

Complement peptide receptors in GtoPdb v.2023.1 [PDF]

, 2023
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A., Woodruff, Trent M.   +8 more
core   +2 more sources

Complement peptide receptors in GtoPdb v.2021.3 [PDF]

, 2021
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [107]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A., Woodruff, Trent M.   +8 more
core   +2 more sources

Anaphylatoxin C3a receptors in asthma [PDF]

, 2005
The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
A Erdei, A Soruri, AA Humbles, AJ Ammit, BE Thangam, C Taube, C Taube, CE Brightling, CE Brightling, DS Faffe, DS Robinson, FF Castro, G Nilsson, H Ali, H Hawlisch, J Ahamed, J Elsner, J Rivera, J Vandermeer, K Hartmann, K Hasegawa, K Kirchhoff, K Maruo, LB Schwartz, MR Woolhiser, MS Huber-Lang, MV Andrade, N Krug, N Shushakova, NG Carroll, NP Gerard, NP Stimler, O Kassel, P Berger, PH Howarth, PJ Daffern, R Baelder, R Gutzmer, R Song, RAJ Panettieri, RC Strunk, RT Venkatesha, S Kawamoto, S Nagata, S Page, S Varsano, SC Bischoff, SM Drouin, SM Drouin, SM Drouin, T Tsujimura, T Werfel, U Oltmanns, W Bautsch, Y Amrani, Y Furumoto, Y Nakano   +56 more
core   +6 more sources

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2020
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xiang X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A., Woodruff, Trent M.   +8 more
core   +2 more sources

The association between serum complement C3a and severity in patients with community-acquired pneumonia [PDF]

, 2023
BackgroundA few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure.
Chun-Mei Feng, De-Xiang Xu, Hui Zhao, Hui Zhao, Lin Fu, Lin Fu, Lin Fu, Ling Zheng, Xue-Feng Hou, Zheng Xu, Zheng Xu, Zheng Xu   +11 more
core   +1 more source

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood [PDF]

, 2022
We found that compstatin, which inhibits the cleavage of complement component C3 to its components C3a and C3b, reduced the E. coli-induced platelet aggregation by 42%-76% (p = 0.0417).
Brekke, Ole Lars, Christiansen, Dorte, Emblem, Åse, Gerogianni, Alexandra, Karlsen, Bård Ove, Landsem, Anne, Lau, Corinna, Mollnes, Tom Eirik, Nilsson, Per   +8 more
core   +1 more source

Role of Complement Activation in Obliterative Bronchiolitis Post Lung Transplantation [PDF]

, 2013
Obliterative bronchiolitis (OB) post lung transplantation involves IL-17 regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation.
Benson, Heather L., Brown, Krista M., Devore, Denise, Fan, Lin, Gu, Hongmei, Lasaro, Melissa, Lasbury, Mark E., Lipking, Kelsey, Love, Robert, Mickler, Elizabeth A., Pandya, Pankita, Reynolds, John, Sandusky, George E., Shilling, Rebecca, Suzuki, Hidemi, Vittal, Ragini, Wagner, Sarah R., Wang, Yi, Weber, Daniel J., Wilkes, David S., Wozniak, Thomas, Wu, Qiang   +21 more
core   +1 more source

Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]

, 2014
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W., Gracon, Adam, Gu, Hongmei, Mickler, Elizabeth A., Sandusky, George E., Vittal, Ragini, Weber, Daniel J., Wilkes, David S., Woodruff, Trent   +8 more
core   +1 more source

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura [PDF]

, 2013
Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been identified in Thrombotic Thrombocytopenic Purpura (TTP).
Heelas, E, Langley, K, Machin, SJ, Scully, M, Westwood, JP   +4 more
core   +1 more source