Results 161 to 170 of about 792,617 (213)
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Purification and crystallization of Complement C3b
Protocol Exchange, 2006Abdul Ajees Abdul Salam +5 more
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Crystallization of human methylamine-treated complement C3 and C3b
Acta Crystallographica Section D Biological Crystallography, 1994Human methylamine-treated complement C3 (C3-MA) and C3b (C3b-MA) have been crystallized using ammonium sulfate as precipitant. The crystals of the two compounds are morphologically indistinguishable though they belong to different space groups. We show that only minor alterations in packing are responsible for the change in space group.
A H, Sørensen +5 more
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[Binding of activated C3b component with complement effector].
Bioorganicheskaia khimiia, 1985Various nucleophilic agents (acceptors) react with thiolester group of nascent activated fragment (C3b) of the third complement component. The C3b-acceptors binding prevents transformation of C3 convertase to C5 convertase and results in inhibition of the cell-target lysis.
L V, Kozlov +3 more
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Human receptor for C3b/C4b: Complement receptor type I
1987Publisher Summary Receptor function and protein are shown to reside on cells of the myelomonocytic series, mature B lymphocytes, glomerular podocytes, a small population of T lymphocytes, follicular dendritic cells, and even in plasma. The purification scheme to be described in the chapter has made available amounts of purified CR1 sufficient for ...
W W, Wong, D T, Fearon
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Methods for assaying nine bovine complement components and C3b-inactivator
Molecular Immunology, 1980Abstract Methods are presented for titrating bovine C3b-inactivator, C2, C3 and C4† by non-hemolytie means, and for assaying all the components of bovine complement except C2 by hemolysis. All components were detected at serum dilutions above 1:1000, and some at dilutions above 1:100,000.
W D, Linscott, R P, Triglia
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The Journal of Immunology, 1979
Abstract Treatment of 125I-C3b bound to EAC1423b with C3b inactivator (C3bINA) and β1H globulin (β1H) cleaved the α-chain of C3b into 65,000- and 42,000-dalton fragments, both of which remained disulfide-bonded to the intact β-chain (C3bi). Subsequent treatment with trypsin (0.1 µg/ml) released 125I into the supernatant and yielded cells
Jaime R Carlo +3 more
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Abstract Treatment of 125I-C3b bound to EAC1423b with C3b inactivator (C3bINA) and β1H globulin (β1H) cleaved the α-chain of C3b into 65,000- and 42,000-dalton fragments, both of which remained disulfide-bonded to the intact β-chain (C3bi). Subsequent treatment with trypsin (0.1 µg/ml) released 125I into the supernatant and yielded cells
Jaime R Carlo +3 more
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Molecular Immunology, 1999
Amplification of complement activation in blood and serum starts on multi-protein complexes that act as precursors of an alternative C3 convertase. Among these covalently linked C4b-, C3b-, and IgG-containing complexes C3b-C3b-IgG complexes represent the major species containing C3b and IgG.
E, Jelezarova, H U, Lutz
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Amplification of complement activation in blood and serum starts on multi-protein complexes that act as precursors of an alternative C3 convertase. Among these covalently linked C4b-, C3b-, and IgG-containing complexes C3b-C3b-IgG complexes represent the major species containing C3b and IgG.
E, Jelezarova, H U, Lutz
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C3b and factor H: key components of the complement system
Expert Review of Clinical Immunology, 2006In all three complement pathways, the central molecule is C3, which, upon activation cleavage, forms the major opsonin C3b - the key component of complement. C3b is also essential for propagation of the complement cascade to the stage of the lytic terminal complement complexes.
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Blood, 2003
AbstractWe investigated deposition of the complement protein fragment C3b and its breakdown products (collectively designated as C3b(i)) on CD20-positive cells treated with rituximab (RTX) in the presence of normal human serum (NHS). Radioimmunoassay (RIA) demonstrates that about 500 000 C3b(i) molecules deposit per cell, and fluorescence microscopy ...
Adam D, Kennedy +7 more
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AbstractWe investigated deposition of the complement protein fragment C3b and its breakdown products (collectively designated as C3b(i)) on CD20-positive cells treated with rituximab (RTX) in the presence of normal human serum (NHS). Radioimmunoassay (RIA) demonstrates that about 500 000 C3b(i) molecules deposit per cell, and fluorescence microscopy ...
Adam D, Kennedy +7 more
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[Erythrocyte complement receptor (C3b) expression in multiple sclerosis].
Neurologia i neurochirurgia polska, 1991The study was carried out in 121 patients with multiple sclerosis and a control group of 519 healthy individuals. In 13 cases of multiple sclerosis and 12 controls family studies were carried out. Complement receptors (C3bR) on the erythrocytes were demonstrated by the haemagglutination test using human IgG heat-aggregated and guinea pig serum which ...
J, Nowak, M, Wender
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