Results 11 to 20 of about 1,533 (97)

CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]

, 1991
Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P., Estaller, C., Koistinen, V., Schwaeble, W., Weiss, Elisabeth H.   +4 more
core   +2 more sources

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age‐Related Macular Degeneration

Disease Markers, Volume 2019, Issue 1, 2019., 2019
Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age‐related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD,
Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Gedvilaite, Kriste Kaikaryte, Loresa Kriauciuniene, Taina K. Lajunen   +5 more
wiley   +1 more source

The Importance of C4d in Biopsies of Kidney Transplant Recipients

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
Antibody‐mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever‐increasing interest in the role of antibody‐mediated mechanisms in allograft rejection.
Rosana Rosa Miranda Corrêa, Juliana Reis Machado, Marcos Vinícius da Silva, Fernanda Rodrigues Helmo, Camila Souza Oliveira Guimarães, Laura Penna Rocha, Ana Carolina Guimarães Faleiros, Marlene Antônia dos Reis, Aron Chakera   +8 more
wiley   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley   +1 more source

Buoyancy regulation and aggregate formation in Amoebobacter purpureus from Mahoney lake [PDF]

, 1992
The meromictic Mahoney Lake (British Columbia, Canada) contains an extremely dense layer of purple sulfur bacteria (Amoebobacter purpureus). The buoyant density of Amoebobacter cells grown in pure culture at saturating light intensity was significantly ...
Bar-Ness, Bar-Or, Booker, Bryant, Bührer, Caldwell, Cline, Courtney, Dahlbäck, Dietrich, Doyle, Eichler, Fattom, Hart, Hartree, Herbert, Huheey, Hutchinson, Jenkinson, Jörg Overmann, Kjelleberg, Lehninger, Marshall, Mas, Nikovskaya, Norbert Pfennig, Northcote, Northcote, Northcote, Ofek, Oliver, Oliver, Overmann, Overmann, Overmann, Parker, Pfennig, Reed, Rosenberg, Siefert, Takakuwa, Tilzer, Walsby, Walsby   +43 more
core   +1 more source

High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Autism Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency.
Naghi Momeni, Lars Brudin, Fatemeh Behnia, Berit Nordström, Ali Yosefi-Oudarji, Bengt Sivberg, Mohammad T. Joghataei, Bengt L. Persson, Judy Van de Water   +8 more
wiley   +1 more source

Inhibitors of Complement Activity in Human Breast‐Milk: A Proposed Hypothesis of Their Physiological Significance

Mediators of Inflammation, Volume 8, Issue 2, Page 69-75, 1999., 1999
Several natural components abundant in the fluid phase of human breast‐milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement ...
Michael Oladipo Ogundele
wiley   +1 more source

Complement System Part II: Role in Immunity [PDF]

, 2015
International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique, Halbwachs-Mecarelli, Lise, Merle, Nicolas S., Noe, Remi, Roumenina, Lubka T.   +4 more
core   +13 more sources

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]

, 2016
Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz, Bajzar, Boehme, Bossi, Campbell, Conway, de Córdoba S, Delvaeye, Dragon-Durey, Esmon, Esmon, Esmon, Esparza-Gordillo, Faust, Fuentes-Prior, Gordon, Hakobyan, Hamad, Harris, Heurich, Hindmarsh, Honda, Huntington, Ikeda, Ito, Jokiranta, Kavanagh, Li, Light, Maga, Markiewski, Martinez-Barricarte, Mayer, Meri, Mizuno, Moll, Morgan, Mouksassi, Noris, Owen, Pangburn, Sadler, Sadler, Saito, Salem, Sawada, Schramm, Shental-Bechor, Suzuki, Tateishi, Tortajada, Udagawa, Vincent, Walport, Walport, Wu, Yada, Yamamoto, Zushi   +58 more
core   +2 more sources

Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome [PDF]

, 2011
Mutations and polymorphisms of factor H gene (FH1) are known to be closely involved in the developmentof atypical hemolytic uremic syndrome (aHUS). Several groups have identified disease risk mutations andpolymorphisms of FH1 for the development of aHUS,
Fujihara Noriko, Hidaka Yoshihiko, Hirota-Kawadobora Masako, Honda Takayuki, Koike Kenichi, Kubota Seiko, Matsuda Kazuyuki, Mukai Saki, Takezawa Yuka, Yamauchi Kazuyoshi, 山内 一由   +10 more
core   +1 more source