Results 121 to 130 of about 3,130 (159)

Circulating complement (C3),C3c and immune complexes in ABPA patients

Serodiagnosis and Immunotherapy in Infectious Disease, 1990
Abstract Complement (C3), its split product (C3c), CRP and circulating immune complexes were studied in 10 patients with allergic bronchopulmonary aspergillosis (ABPA) and compared with 10 age and sex matched controls. An insignificant decrease and significant increase in the levels of C3 and C3c, respectively, was observed in ABPA patients in ...
Banani Banerjee, P Usha Sarma
exaly   +2 more sources

Hypercatabolism of Complement in Crohn's Disease—Assessment of Circulating C3c

Journal of Internal Medicine, 1983
ABSTRACT. Split products from the main complement component 3 (C3) were investigated in untreated outpatients, 20 with Crohn's disease and 20 with ulcerative colitis. The median plasma concentration of c split product of C3 (C3c) in normals was 2 mg·l‐1, in patients with Crohn's disease 20 mg·l‐1 and in patients with ulcerative colitis 3 mg·l‐1.
J Elmgreen, H Sørensen
exaly   +3 more sources

A single step immunoelectrophoresis method for the quantitation of complement C3c in biological fluids

Journal of Immunological Methods, 1983
An intermediate gel rocket immunoelectrophoresis (IRI) suitable for direct quantitation of complement split products with C3c specificity is described. The technique represents a simple, quick, and reproducible method for the assessment of complement activity in biological fluids in diseases.
H Sørensen
exaly   +3 more sources

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition * [PDF]

Journal of Biological Chemistry, 2007
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of the activation of complement component C3 and thus blocks a central and crucial step in the complement cascade.
Piet Gros, Bert J C Janssen, John D. Lambris   +2 more
exaly   +5 more sources

Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson’s disease

Biochemical and Biophysical Research Communications, 2006
We have used quantitative 2D gel electrophoresis to analyze serum proteins from 422 patients with neurodegenerative diseases and normal individuals in an unbiased approach to identify biomarkers. Differences in abnormal serum levels were found between amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and related disorders for 34 protein ...
Albert A. Yen, Stanley H Appel, Ira L Goldknopf   +2 more
exaly   +3 more sources

Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3

Journal of Immunological Methods, 2010
There is a general need for markers of systemic inflammation in acute or chronic diseases, where complement activation is involved. Available methods to monitor complement activation are elaborate and of low sensitivity; they include haemolytic assays (CH50), quantification of fluid phase terminal complex (C5b-C9) and quantification of complement split
Yaseelan Palarasah, BØRge Teisner, Claus Koch   +2 more
exaly   +5 more sources

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b [PDF]

Journal of Molecular Biology, 2010
The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of complement component 3 (C3) into the potent opsonin C3b, which triggers a variety of immune responses and participates in a self-amplification
Daniel Ricklin, Brandon L Garcia, John D. Lambris   +2 more
exaly   +3 more sources

Isolation of the porcine complement activation fragments C3c and C3d and their use in the preparation of monospecific antibodies

Veterinary Immunology and Immunopathology, 1993
The hemolytic test to date has been the sole analytic technique applied to study the complement reaction in the swine. To improve the analytical possibilities for this species we have developed polyclonal antibody reagents with specificities for the C3c and C3d activation fragments of swine C3. Access to these reagents, by which activation products can
U R Nilsson, Ulf R Nilsson
exaly   +3 more sources

Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis [PDF]

Histopathology, 2010
Detlefsen S, Bräsen J H, Zamboni G, Capelli P & Klöppel G
(2010) Histopathology57, 825–835 Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis Aims:  Autoimmune pancreatitis (AIP) is a type of pancreatitis whose immunopathogenesis is still unknown. It has been
Giuseppe Zamboni, Günter Klöppel, Sönke Detlefsen   +2 more
exaly   +5 more sources

Inhibition of the classical activation pathway of complement‐mediated lysis by monoclonal antibodies to complement components C3c and C3d

Transfusion, 1992
Eight epitope‐mapped monoclonal antibodies (MoAbs) to complement component C3d and five to complement component C3c were investigated to determine whether they could inhibit the classical activation pathway of complement‐mediated lysis (CML) by using blood group AB red cells sensitized by A or B MoAbs.
R E, Mushens, T, Bakacs
openaire   +2 more sources