Results 181 to 190 of about 790,520 (218)

Multicentre physiological reference intervals for serum concentrations of immunoglobulins A, G and M, complement C3c and C4 measured with Tina-Quant® reagents systems

Clinical Chemistry and Laboratory Medicine, 2007
X. Fuentes-Arderiu, Eduardo Alonso-Gregorio, V. Álvarez-Funes, Carmen Ambrós-Marigómez, Lluís Coca-Fábregas, Marta Cruz-Placer, Julián Díaz-Fernández, María Pilar Pinel-Julián, B. Gutiérrez-Cecchini, Pilar Herrero-Bernal, M. Sempere-Alcocer, F. García-Caballero, María del Mar Larrea-Ortiz-Quintana, P. La-Torre-Marcellán, María del Señor López-Vélez, C. Mar-Medina, Javier Martín-Oncina, M. V. Rodríguez-Hernández, María Victoria Romero-Sotomayor, Cándido Serrano-López, Adolfo Sicilia-Enríquez-de-Salamanca, Ana María Velasco-Romero, Santiago Juvé-Cuxart   +22 more
semanticscholar   +3 more sources

Inhibition of the classical activation pathway of complement‐mediated lysis by monoclonal antibodies to complement components C3c and C3d

Transfusion, 1992
Eight epitope‐mapped monoclonal antibodies (MoAbs) to complement component C3d and five to complement component C3c were investigated to determine whether they could inhibit the classical activation pathway of complement‐mediated lysis (CML) by using blood group AB red cells sensitized by A or B MoAbs.
R E, Mushens, T, Bakacs
openaire   +2 more sources

Structure of C3c in complex with compstatin reveals a new mechanism of complement inhibition

Molecular Immunology, 2007
Bert Janssen - Conformational Complexity of Complement Component C3 60 Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of C3 activation thus preventing a central and crucial step in ...
Bert J.C. Janssen, Els Halff, John D. Lambris, Piet Gros   +3 more
openaire   +1 more source

Isolation of the porcine complement activation fragments C3c and C3d and their use in the preparation of monospecific antibodies

Veterinary Immunology and Immunopathology, 1993
The hemolytic test to date has been the sole analytic technique applied to study the complement reaction in the swine. To improve the analytical possibilities for this species we have developed polyclonal antibody reagents with specificities for the C3c and C3d activation fragments of swine C3. Access to these reagents, by which activation products can
K E, Storm, U R, Nilsson
openaire   +2 more sources

Serum complement C3c concentration in non-obese young insulin-resistant Mexicans.

Diabetes, nutrition & metabolism, 2003
The aim of this study was to compare the serum complement C3 concentration between non-obese young insulin-sensitive and insulin-resistant Mexicans. A cross-sectional study was carried out in 28 healthy, non-obese [Body mass index (BMI) < 26 kg/m2] young (age 19-25 yr), male volunteers to measure the serum C3 concentration.
M, González-Ortiz, E, Martínez-Abundis, F, Grover-Páez, S, Pascoe-González   +3 more
openaire   +1 more source

Development and clinical application of electroimmunoassays for the direct quantification of the complement C3 split products C3c and C3d

Scandinavian Journal of Clinical and Laboratory Investigation, 1984
The present report describes the development of electroimmunoassays for the direct quantification of C3d and C3c, split products of the third complement factor (C3). Both methods were developed as rocket immunoelectrophoreses, using two antibody preparations with specificities against the C and D epitopes on C3.
I, Brandslund, B, Teisner, P, Hyltoft Petersen, S E, Svehag   +3 more
openaire   +2 more sources

Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton.

International Immunopharmacology
Complement factor H (CFH), mainly produced in the liver, is a key alternative complement pathway regulator. Recent studies unveiled some novel functions of CFH independent of complement activation.
Yebei Li, Xinran Ni, Xianzhi Li, Yuqi Kang, Xiaohan Yuan, Gaosi Xu, Taoran Wang, Di Li, S. Shi, Jicheng Lv, Minghui Zhao, Hong Zhang, Li Zhu   +12 more
semanticscholar   +1 more source

Complement C3c and C3d in plasma and synovial fluid in rheumatoid arthritis.

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology, 1984
By means of recently developed immunochemical assays increased levels of the complement C3c and C3d split products were found in synovial fluids of patients with rheumatoid arthritis (RA) as compared with synovial fluids of patients with traumatic synovitis (TS). In plasma, only the C3d levels were significantly increased compared with plasma levels of
A, Berkowicz, E, Kappelgaard, J, Petersen, H, Nielsen, T, Ingemann-Hansen, J, Halkjaer-Kristensen, H, Sørensen   +6 more
openaire   +1 more source

In situ assessment of glomerular C3/C5 convertases indicates ongoing complement activation in IgA nephropathy.

Nephrology, Dialysis and Transplantation
BACKGROUND AND HYPOTHESIS The complement system contributes to the progression of IgA nephropathy (IgAN) and offers promising therapeutic targets currently under investigation.
Augustin Obrecht, M. Meuleman, J. Olagne, Anne Grunenwald, Sophie Chauvet, L. Roumenina, V. Frémeaux-Bacchi, Sophie Caillard, Anna Duval   +8 more
semanticscholar   +1 more source

Da-yuan-yin decoction alleviates ulcerative colitis by inhibiting complement activation, LPS-TLR4/NF-κB signaling pathway and NET formation.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Da-yuan-yin decoction (DYY) is a classical traditional Chinese medicine prescription for ulcerative colitis (UC). AIM OF STUDY This study explored the protective effects and mechanisms of DYY on UC.
Yun Yang, Lengqiu Guo, Lan Wei, Jinghua Yu, Song Zhu, Xinyi Li, Jianyu Liu, Rui Liang, Wei Peng, Fei Ge, Zhang Jian   +10 more
semanticscholar   +1 more source