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Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease.

Biochemical and Biophysical Research Communications, 2006
We have used quantitative 2D gel electrophoresis to analyze serum proteins from 422 patients with neurodegenerative diseases and normal individuals in an unbiased approach to identify biomarkers. Differences in abnormal serum levels were found between amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and related disorders for 34 protein ...
I. Goldknopf   +7 more
semanticscholar   +5 more sources

A single step immunoelectrophoresis method for the quantitation of complement C3c in biological fluids.

Journal of Immunological Methods, 1983
An intermediate gel rocket immunoelectrophoresis (IRI) suitable for direct quantitation of complement split products with C3c specificity is described. The technique represents a simple, quick, and reproducible method for the assessment of complement activity in biological fluids in diseases.
A. Berkowicz   +2 more
semanticscholar   +5 more sources

IUD-induced changes in cervical secretion content of albumin, IgG and complement C3c.

Contraception, 1984
Cervical secretion albumin, IgG, complement C3c, spinnbarkeit and amount of wet weight mucus recovered were analyzed in a group of 13 women using IUD as a contraceptive method and the results were compared to those obtained in a control group. Significant differences were obtained when concentrations and amounts of soluble proteins in the respective ...
L. Fleetwood, B. Landgren, P. Eneroth
semanticscholar   +3 more sources

Epitope specificities and quantitative and serologic aspects of monoclonal complement (C3c and C3d) antibodies

Transfusion, 1987
Twenty‐two monoclonal antibodies to human C3c and ten to C3d were obtained by hybridization after the immunization of mice with complement‐coated human red cells and/or purified human complement components. C3c antibodies were variable in their agglutination reactions with cells coated with C3 by antibody in vitro; more consistent and potent reactions ...
D. Dobbie   +3 more
semanticscholar   +3 more sources

Hypercatabolism of Complement in Crohn's Disease—Assessment of Circulating C3c

Acta Medica Scandinavica, 1983
ABSTRACT. Split products from the main complement component 3 (C3) were investigated in untreated outpatients, 20 with Crohn's disease and 20 with ulcerative colitis. The median plasma concentration of c split product of C3 (C3c) in normals was 2 mg·l‐1, in patients with Crohn's disease 20 mg·l‐1 and in patients with ulcerative colitis 3 mg·l‐1.
J, Elmgreen, A, Berkowicz, H, Sørensen
openaire   +4 more sources

Circulating complement (C3),C3c and immune complexes in ABPA patients

Serodiagnosis and Immunotherapy in Infectious Disease, 1990
Abstract Complement (C3), its split product (C3c), CRP and circulating immune complexes were studied in 10 patients with allergic bronchopulmonary aspergillosis (ABPA) and compared with 10 age and sex matched controls. An insignificant decrease and significant increase in the levels of C3 and C3c, respectively, was observed in ABPA patients in ...
P.K. Bhatnagar   +3 more
openaire   +3 more sources

Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3

Journal of Immunological Methods, 2010
There is a general need for markers of systemic inflammation in acute or chronic diseases, where complement activation is involved. Available methods to monitor complement activation are elaborate and of low sensitivity; they include haemolytic assays (CH50), quantification of fluid phase terminal complex (C5b-C9) and quantification of complement split
Palarasah, Yaseelan   +6 more
openaire   +6 more sources

Evidence for C3c Acceptor Sitesfor the Fixation of ComplementRelated Protein Fragments

Journal of Biology and Health Science
Fixation of complement-related protein fragments occurs following treatment of Raji, a CR2-positive lymphoblastoma cell line, with NHS but not with hi-S.From the immunoblot developed by autoradiography of cells pretreated with OKB7, an anti-CR2 ...
Giuseppe Barile
semanticscholar   +2 more sources

Levels of complement components iC3b, C3c, C4, and SC5b-9 in peritoneal fluid and serum of infertile women with endometriosis

Fertility and Sterility, 2007
To assess whether complement components iC3b, C3c, C4, and SC5b-9 may be involved in the pathogenesis of endometriosis.Prospective, experimental trial.Medical university.112 women infertile women undergoing laparoscopy.Venipuncture and laparoscopic peritoneal fluid collection.Peritoneal fluid and serum iC3b, C3c, C4, and SC5b-9 levels were measured by ...
Jacek, Kabut   +3 more
openaire   +4 more sources

Levels of Complement Receptor Type One (CR1, CD35) on Erythrocytes, Circulating Immune Complexes and Complement C3 Split Products C3d and C3c Are Not Changed by Short-Term Physical Exercise or Training

International Journal of Sports Medicine, 1992
The effect of heavy short-term physical exercise on the levels of complement receptor type one (CR1, CD35) on erythrocytes, the concentrations of circulating immune complexes (IC), and the complement C3 split products C3c and C3d were examined in young healthy males.
B S, Thomsen   +6 more
openaire   +4 more sources

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