Results 101 to 110 of about 49,973 (249)

Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus. [PDF]

Viruses, 2021
Emerson CC, Stewart PL.
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes. [PDF]

Front Cell Neurosci, 2023
Veremeyko T, Jiang R, He M, Ponomarev ED.   +3 more
europepmc   +1 more source

Complement C4-A [PDF]

, 2020
openaire   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Correlation Between C4/IgG with Macroproteinuria in Chronic Kidney Disease: A Pilot Study

ImmunoTargets and Therapy
Hao Zhang,1,* Anqi Xu,2,* Xiangxiang Li,3,* Binbin Pan,1 Xin Wan1 1Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Quality Management, Nanjing Red Cross Blood ...
Zhang H, Xu A, Li X, Pan B, Wan X
doaj  

Hereditary angioedema type 1 in a 39-year-old woman with a three-generation pedigree: a case report

Allergy Medicine
Background: Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder, clinically manifested as recurrent localized edema of the skin and mucous membranes, which can involve the gastrointestinal tract and cause severe abdominal pain when ...
Xiaolei Liu, Huali Ren, Xige Liu
doaj   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Complement C4 associations with altered microbial biomarkers exemplify gene-by-environment interactions in schizophrenia. [PDF]

Schizophr Res, 2021
Severance EG, Leister F, Lea A, Yang S, Dickerson F, Yolken RH.   +5 more
europepmc   +1 more source

Non‐Hermitian Stealthy Hyperuniformity

Advanced Science, EarlyView.
A framework for non‐Hermitian extensions of hyperuniformity and stealthiness is proposed, generalizing PT‐symmetric gain‐loss crystals to correlated disorder in the weak‐scattering limit. By engineering real‐imaginary correlations of the material potential, this framework enables directional scattering phases inaccessible in Hermitian materials ...
Gitae Lee, Seungmok Youn, Ikbeom Lee, Kunwoo Park, Duhwan Hwang, Seungkyun Park, Xianji Piao, Namkyoo Park, Sunkyu Yu   +8 more
wiley   +1 more source