Results 81 to 90 of about 49,973 (249)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Effect of olanzapine on changes in serum complement factors levels in patients with first-episode schizophrenia

BMC Psychiatry
Objective An increasing number of studies have demonstrated that patients with schizophrenia (SCZ) exhibit complement system disorders, and alterations in serum complement factor levels may serve as biomarkers for guiding the diagnosis, prognosis, and ...
Yin Cao, Xuan Zhou, Chunyu Yan, Jun Liang, Biao Dai, Qingrong Xia   +5 more
doaj   +1 more source

Relevance of Complement C4 Deposits Localized to Distinct Vascular Compartments in ANCA-Associated Renal Vasculitis. [PDF]

Int J Mol Sci, 2022
Hakroush S, Kluge IA, Baier E, Tampe D, Tampe B.   +4 more
europepmc   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Clinical significance of serum complement levels and C3/C4 ratio in IgA nephropathy: histopathological correlates and prognostic implications

Renal Failure
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Complement activation plays a central role in its pathogenesis; however, the prognostic significance of serum complement levels remains unclear.
Gamze Ergun, Emrullah Tasdemir, Umut Kasapoglu, Arzu Ozdemir   +3 more
doaj   +1 more source

A Study of Serum C3 and C4 Levels in Burn Patients: Possible Prognostic Markers?

JK Science, 2021
Background: Burns are a public health problem across the world and a major burden on health care resources. Identifying major burns including those more likely to develop sepsis will help a lot in their management. Purpose: This study was undertaken to
Sanjay Sadhu, Kiran Bhat
doaj  

Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. [PDF]

J Trauma Acute Care Surg, 2022
Schaid TR, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ.   +14 more
europepmc   +1 more source

A Unified Flash Memory Platform for Mode‐Adaptive and Robust AI Computation

Advanced Science, EarlyView.
A unified AND‐type flash memory platform enables both transistor‐mode and capacitor‐mode computing‐in‐memory operations within the same device structure. By selectively switching the sensing mode through peripheral reconfiguration, the platform provides adaptable trade‐offs between computational accuracy, robustness, and energy efficiency for AI ...
Dayeon Yu, Hwiho Hwang, Byeongchan Oh, Junmo Lee, Shimeng Yu, Tae‐Hyeon Kim, Hyungjin Kim   +6 more
wiley   +1 more source

C-Reactive Protein Levels Are Associated with Complement C4 Deposits and Interstitial Arteritis in ANCA-Associated Renal Vasculitis. [PDF]

Int J Mol Sci, 2023
Korsten P, Baier E, Hakroush S, Tampe B.
europepmc   +1 more source