Results 71 to 80 of about 49,973 (249)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Importance of complement system components in ovarian endometriomas. A comparative cohort study [PDF]

Гинекология
Background. Ovarian endometriomas are one of the most common ovarian neoplasms. There are specific ultrasound criteria for this type of endometriosis; however, in some cases, differential diagnosis from other ovarian tumors is challenging. Aim.
Anna V. Chizhova, Elena V. Kudryavtseva, Larisa G. Polushina, Maksim A. Kopenkin   +3 more
doaj   +1 more source

Serum Complement C4 Levels Are a Useful Biomarker for Predicting End-Stage Renal Disease in Microscopic Polyangiitis. [PDF]

Int J Mol Sci, 2023
Matsuda S, Oe K, Kotani T, Okazaki A, Kiboshi T, Suzuka T, Wada Y, Shiba H, Hata K, Shoda T, Takeuchi T.   +10 more
europepmc   +1 more source

Purification of human complement subcomponent C4 [PDF]

FEBS Letters, 1979
Reboul, A., Thielens, N., Villiers, M.B., Colomb, M.G.   +3 more
openaire   +2 more sources

Ultrafast Optoacoustics Reveals Intricate 3D Anisotropic Elasticity in Nanocrystalline Membranes

Advanced Science, EarlyView.
Ultrafast optoacoustic spectroscopy combined with a Sagnac interferometer enables non‐contact, simultaneous characterization of thickness and the full three‐dimensional anisotropic elastic constants in freestanding nanocrystalline copper membranes. By capturing gigahertz Lamb waves and zero‐group‐velocity resonances followed by SAFE‐GA inversion, the ...
Shuchang Zhang, Yi He, Guojie Luo, Jie Huang, Pak San Yip, Haoyu Cui, Wanglinhan Zhang, Zijian Wang, Lin Ye, Yang Lu, Zhongqing Su, Yehai Li   +11 more
wiley   +1 more source

SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet

Advanced Science, EarlyView.
SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv, Jinjin Cheng, Zhen Hu, Qian Lan, Yanjun Yang, Chengcheng Pei, Junhao Luo, Zhuang Li, Peiyong Xin, Jijun Yan, Jinfang Chu, Qian Qian, Zhaosheng Kong, Liang Jiang   +13 more
wiley   +1 more source

Hypocomplementemia in Primary Sjogren’s Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients

International Journal of General Medicine, 2022
Meiju Zhou, Fang Yuan Department of Rheumatology and Immunology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Fang YuanDepartment of Rheumatology and ...
Zhou M, Yuan F
doaj  

Complement C4 - A Genetic Marker in Arthritides

International Journal of Human Genetics, 2004
KEYWORDS Complement C4; juvenile arthritis; rheumatoid arthritis; osteo arthritis; phenotypes; arthritides ABSTRACT The present study aims at evaluating the role of complement C4 and its specific eletromorphic association with arthritides. C4 typing of the serum samples was carried out by PAGE on 41 juvenile arthritis, 101 rheumatoid arthritis, 25 ...
A. Padmini, Ravi Babu, N. Pratibha
openaire   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source