Results 211 to 220 of about 942,109 (243)

Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

Human Genetics, 1982
A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather ...
G, Bruun-Petersen, L U, Lamm, B K, Jacobsen, T, Kristensen   +3 more
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Sex, MHC and complement C4 in autoimmune diseases

Trends in Immunology, 2004
Autoimmune diseases are estimated to affect 10-50 million people in the United States, and untold millions worldwide. Nearly 80% of all people with autoimmune diseases are women, and a strong association of these diseases with MHC genes has been known for some time. However, very little is known about what causes autoimmune diseases or the factors that
C Yung, Yu, Caroline C, Whitacre
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C4A7: A New Variant of Human Complement C4

Human Heredity, 1988
A rare variant of complement C4 was found in 2 related individuals. It has the most anodic mobility found to date, no hemolytic activity detected by the overlay technique and a Bgl II RFLP pattern very similar to that of the C4A6 type.
M, Abbal, F, de Paoli, M, Cuccia-Belvedere, M, Martinetti   +3 more
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Genetic polymorphism of complement C4 in the dog

Tissue Antigens, 1984
Plasma samples from 129 dogs have been typed using an immunofixation technique to define the polymorphism of canine C4. The mode of inheritance was inferred by study of four large pedigrees. In contrast to the situation in man, canine C4 may be encoded by a single locus. At least five different co‐dominant structural alleles have been detected.
P H, Kay, R L, Dawkins
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The complement component C4 in sudden infant death

European Journal of Pediatrics, 1999
The aim of the present study was to compare partial deletions of the complement C4 gene in victims of totally unexplained sudden infant death (SID) (n = 89) and borderline SID (n = 15) with and without slight infections prior to death, in cases of infectious death (n = 19), and in living infants with and without infections (n = 84).
S H, Opdal, A, Vege, A K, Stave, T O, Rognum   +3 more
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Interaction of nucleophilic compounds with complement component C4

Comparative Immunology, Microbiology and Infectious Diseases, 1988
Drugs which induce systemic lupus erythematosus as a toxic side effect have been shown to inhibit the covalent binding of C4, which is an important event in immune complex clearance in normal individuals. Human C4 is encoded at two polymorphic loci, C4A and C4B within the Major Histocompatibility Complex and patients with idiopathic SLE are more likely
E, Sim, M, Wood, K E, Parker, A, Jones
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Complement C4 Phenotypes in Dementia of the Alzheimer Type

Human Heredity, 1988
Complement C4 phenotype distribution was studied in 64 patients with dementia of the Alzheimer type. In contrast to reported findings we failed to find a significant association between C4B2 gene frequency and Alzheimer's dementia.
Eikelenboom, P., Goetz, J., Pronk, J. C., Hauptmann, G.   +3 more
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Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse

Immunogenetics, 1990
The expression of the fourth component of complement (C4) of the mouse can differ 20-fold and is determined by C4-high (C4h) or C4-low (C4l) alleles. To investigate the molecular mechanisms underlying the differences in C4 expression, we compared the transcriptional activity of the C4 genes between high and low C4-producer strains of mice (B10 and FM ...
K, Nakayama, S, Pattanakitsakul, S, Yokoyama, H, Kimura, M, Nonaka, M, Takahashi   +5 more
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Reference Typing Report for Complement Component C4

Experimental and Clinical Immunogenetics, 1998
During the 7th Complement Genetics Workshop, Mainz, Germany, May 1998, a complement component C4 typing exercise took place with the aim of applying present technologies to the definition of <i>reference C4 alleles/phenotypes</i> and the recognition of nonexpressed (Q0) C4 alleles within expressed haplotypes.
G. Mauff, Birgit Luther, P.M. Schneider, C. Rittner, Beate Stradmann-Bellinghausen, R. Dawkins, Joann M. Moulds   +6 more
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Complement: Optimal Reaction Conditions for Guinea Pig C4

The Journal of Immunology, 1973
Abstract The efficiency of reactions involving C4 was markedly affected by antibody class, antibody concentration, temperature, ionic strength, SAC1 multiplicity, and SA:SAC1 ratio; C1-binding affinity was an important factor. Invariably, IgG-sensitized cells showed more lysis with a given amount of C4 than cells treated with IgM when ...
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