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Complement factor C4 activation in patients with hereditary angioedema
Clinical Biochemistry, 2017Low complement factor C4 is usually considered a valuable screening tool for patients with the potentially life-threatening hereditary angioedema with C1-inhibitor (C1-INH) deficiency (C1-INH-HAE). However, there are patients with C1-INH-HAE presenting with normal C4 levels.
Anne Aabom, Anette Bygum, Claus Koch
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Complement Inhibitors Targeting C3, C4, and C5
2000Activation of the complement system (Fig. 1) is the key to the development of normal inflammatory responses against foreign pathogens. During the course of this activation process a number of biological events are initiated, including generation of small peptides that induce local inflammatory responses, tagging of foreign pathogens with complement ...
Arvind Sahu +2 more
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COMPLEMENT C4 ALLOTYPES IN ALZHEIMER'S DISEASE
The Lancet, 1982C W, Nerl, R, Mayeux, G J, O'Neill
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Polymorphism of the human complement component C4.
Experimental and clinical immunogenetics, 1990The genes encoding the two C4 isotypes, C4A and C4B, lie 10 kb apart in the class III region of the human major histocompatibility complex. The two isotypes exhibit extensive structural polymorphism. Characterisation of a number of C4A and C4B alleles has established the pattern of polymorphism in C4 and this has provided a structural basis for the ...
R D, Campbell +3 more
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Complement C4 types in coeliacs and controls
Irish Journal of Medical Science, 1991J, Cahill, F M, Stevens, C F, McCarthy
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Chido and Rodgers blood groups are distinct antigenic components of human complement C4
Nature, 1978G. O'Neill +4 more
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Complement C4 Protein and DNA Typing Methods
2003Peter M, Schneider, Gottfried, Mauff
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