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Complement C4 and Autoimmune Diseases
The Journal of ImmunologyAbstract Complement activation on autologous cells causes tissue injuries but the process is not well studied. We seek to elucidate how C4 variants, their activation products and isotype deficiencies contribute to increased risks of children systemic lupus erythematous (cSLE) and juvenile dermatomyositis (JDM).
Danlei Zhou +10 more
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Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse
Immunogenetics, 1990The expression of the fourth component of complement (C4) of the mouse can differ 20-fold and is determined by C4-high (C4h) or C4-low (C4l) alleles. To investigate the molecular mechanisms underlying the differences in C4 expression, we compared the transcriptional activity of the C4 genes between high and low C4-producer strains of mice (B10 and FM ...
K, Nakayama +5 more
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Reference Typing Report for Complement Component C4
Experimental and Clinical Immunogenetics, 1998During the 7th Complement Genetics Workshop, Mainz, Germany, May 1998, a complement component C4 typing exercise took place with the aim of applying present technologies to the definition of <i>reference C4 alleles/phenotypes</i> and the recognition of nonexpressed (Q0) C4 alleles within expressed haplotypes.
G. Mauff +6 more
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Complement: Optimal Reaction Conditions for Guinea Pig C4
The Journal of Immunology, 1973Abstract The efficiency of reactions involving C4 was markedly affected by antibody class, antibody concentration, temperature, ionic strength, SAC1 multiplicity, and SA:SAC1 ratio; C1-binding affinity was an important factor. Invariably, IgG-sensitized cells showed more lysis with a given amount of C4 than cells treated with IgM when ...
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Complement factor C4 activation in patients with hereditary angioedema
Clinical Biochemistry, 2017Low complement factor C4 is usually considered a valuable screening tool for patients with the potentially life-threatening hereditary angioedema with C1-inhibitor (C1-INH) deficiency (C1-INH-HAE). However, there are patients with C1-INH-HAE presenting with normal C4 levels.
Anne Aabom, Anette Bygum, Claus Koch
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Complement Inhibitors Targeting C3, C4, and C5
2000Activation of the complement system (Fig. 1) is the key to the development of normal inflammatory responses against foreign pathogens. During the course of this activation process a number of biological events are initiated, including generation of small peptides that induce local inflammatory responses, tagging of foreign pathogens with complement ...
Arvind Sahu +2 more
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COMPLEMENT C4 ALLOTYPES IN ALZHEIMER'S DISEASE
The Lancet, 1982C W, Nerl, R, Mayeux, G J, O'Neill
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Polymorphism of the human complement component C4.
Experimental and clinical immunogenetics, 1990The genes encoding the two C4 isotypes, C4A and C4B, lie 10 kb apart in the class III region of the human major histocompatibility complex. The two isotypes exhibit extensive structural polymorphism. Characterisation of a number of C4A and C4B alleles has established the pattern of polymorphism in C4 and this has provided a structural basis for the ...
R D, Campbell +3 more
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