Results 91 to 100 of about 675,301 (233)

The disease‐linked R336C mutation in cystathionine β‐synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

The FEBS Journal, EarlyView.
Cystathionine β‐synthase (CBS) is an essential enzyme involved in cysteine metabolism. The mutation R336C, associated with severe homocystinuria and of high incidence in Qatar, reduces its activity. Our research shows that this mutation does not destabilize the enzyme fold but subtly alters the tautomeric equilibrium of the PLP cofactor within the ...
Carolina Conter, Reyes Núñez‐Franco, Duaa Walid Al‐Sadeq, Carmen Fernández‐Rodríguez, Naroa Goikoetxea‐Usandizaga, Gheyath K. Nasrallah, Michail Nomikos, Maria Luz Martinez‐Chantar, Alessandra Astegno, Gonzalo Jiménez‐Osés, Luis Alfonso Martínez‐Cruz   +10 more
wiley   +1 more source

Screening Biomarkers of Sudden Coronary Death Based on mRNA Expression Profile of Rat Myocardial Tissues

Fayixue Zazhi, 2022
ObjectiveTo explore the differential expression of messenger RNA （mRNA） in myocardial tissues of rats with sudden coronary death （SCD）, and to provide ideas for the forensic identification of SCD.MethodsThe rat SCD model was established, and the ...
GUO Xiang-jie, LI Hao, BAI Ya-qin, WU Peng, ZHAO Chun-mei, DONG Yi-ming, CHEN Nian-nian, YUN Ke-ming, GAO Cai-rong   +8 more
doaj   +1 more source

Sex‐dimorphic gene regulation in murine macrophages across niches

Immunology &Cell Biology, EarlyView.
In this study, we perform a meta‐analysis of new and publicly available RNA‐seq datasets from male and female mouse macrophages across eight niches to identify conserved sex‐dimorphic gene expression patterns. We found that three sex chromosome‐linked genes are always differentially expressed between males and females: Ddx3y, Eif2s3y and Xist. However,
Cassandra J McGill, Olivia S White, Ryan J Lu, Nirmal K Sampathkumar, Bérénice A Benayoun   +4 more
wiley   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Natural antibodies and CRP drive anaphylatoxin production by urate crystals

Scientific Reports, 2022
In gout, crystallization of uric acid in the form of monosodium urate (MSU) leads to a painful inflammatory response. MSU crystals induce inflammation by activating the complement system and various immune cell types, and by inducing necrotic cell death.
Anne Kathrin Wessig, Leonie Hoffmeister, Annika Klingberg, Anika Alberts, Andreas Pich, Korbinian Brand, Torsten Witte, Konstantin Neumann   +7 more
doaj   +1 more source

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes

Frontiers in Cellular Neuroscience, 2023
Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated an important role of complement subunits C1q, C4, and C3 in normal functions of the central nervous system (CNS) such as non ...
Tatyana Veremeyko, Tatyana Veremeyko, Tatyana Veremeyko, Rongcai Jiang, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev, Eugene D. Ponomarev, Eugene D. Ponomarev   +8 more
doaj   +1 more source

Validating the parental reflective functioning questionnaire ‐ infant version using a rasch model

Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 4, Page 445-458, July 2025.
Abstract Parental reflective functioning is the parent's ability to reflect on the psychological processes in their child and in themselves as a parent. Recently, an infant version of the Parental Reflective Functioning Questionnaire, PRFQ‐I, has been developed and validated using confirmatory factor analyses.
Anne Christine Stuart, Ida Egmose, Katrine Isabella Wendelboe, Johanne Smith‐Nielsen, Mette Skovgaard Væver   +4 more
wiley   +1 more source

Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

Annals of Neurology, Volume 97, Issue 5, Page 1007-1018, May 2025.
The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators.
Alison M. H. Donald, Luiz G. N. de Almeida, Mohamed Ziad Dabaja, Isabella Orchard, Kaia Ybema, Veronica Tsegai, Victoria Armstrong, Sophie Smith, Daniel Young, Richard Stewart Longman, Amanda V. Tyndall, Jean M. Rawling, Michael D. Hill, Willis H. Tsai, Ejaife Agbani, Marc J. Poulin, Antoine Dufour   +16 more
wiley   +1 more source

Complement genes contribute sex-biased vulnerability in diverse disorders [PDF]

, 2020
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjogren's syndrome affect nine times more women than men1, whereas ...
Daly, Mark, Eriksson, Johan, Handsaker, Robert E., Kamitaki, Nolan, McCarroll, Steven A., Palotie, Aarno, Paunio, Tiina, Pietiläinen, Olli, Schizophrenia Working Grp Psychiat, Sekar, Aswin   +9 more
core   +1 more source

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática Association of the C4A6 rare allotype with rheumatic heart disease

Revista Brasileira de Reumatologia, 2004
OBJETIVO: determinar se os alótipos do Fator B (BF), C2 e C4 (C4A e C4B) do sistema complemento poderiam ser marcadores para a doença cardíaca reumática (DCR) na população brasileira. MÉTODOS: foram estudados 49 pacientes com DCR crônica.
Iara Jose de Messias-Reason, Ednéia Cavalcanti, Sebastião Cézar Radominski   +2 more
doaj   +1 more source