Results 111 to 120 of about 11,949 (217)

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng, Jennifer Nolz, Timothy Karr, Nicole Dorn, Benjamin Readhead, Rosa Krajmalnik‐Brown, Diego Mastroeni   +6 more
wiley   +1 more source

Non‐Targeted Analysis of Extracellular Vesicle‐Enriched Plasma Proteome Between Early and Late Rugby Playing Career

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Purpose Rugby players experience high‐impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biomarkers to indicate differential risk associated with a rugby career.
Abhishek Jagan, Yusuke Nishimura, Tim Donovan, Jatin G. Burniston   +3 more
wiley   +1 more source

Lexicographic choice functions [PDF]

, 2017
We investigate a generalisation of the coherent choice functions considered by Seidenfeld et al. (2010), by sticking to the convexity axiom but imposing no Archimedeanity condition. We define our choice functions on vector spaces of options, which allows
de Cooman, Gert, Miranda, Enrique, Van Camp, Arthur   +2 more
core   +4 more sources

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli

Kidney International, 1986
Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Feucht, Helmut E., Jung, Christina M., Gokel, Michael J., Riethmüller, Gert, Zwirner, Jörg, Brase, Angelika, Held, Eckhard, O'Neill, Geoffrey J.   +7 more
openaire   +2 more sources

Complement mediated inhibition of immune precipitation and solubilization generate different concentrations of complement anaphylatoxins (C4a, C3a, C5a).

Clinical and experimental immunology, 1986
Complement prevents the formation of insoluble immune complexes (inhibition of immune precipitation (IIP], and solubilizes preformed immune aggregates (solubilization (SOL]. Since the mechanism of complement activation differs in these two reactions, it is possible that they differ also in the amount of complement fragments released, in particular the ...
Jürg A. Schifferli, G Steiger, J P Paccaud   +2 more
openalex   +3 more sources

Association Study of the Complement Component C4 Gene in Tardive Dyskinesia

Frontiers in Pharmacology, 2019
Tardive dyskinesia (TD) is a movement disorder that may develop in schizophrenia patients being treated long-term with antipsychotic medication. TD interferes with voluntary movements and leads to stigma, and can be associated with treatment non ...
Clement C. Zai, Clement C. Zai, Clement C. Zai, Clement C. Zai, Arun K. Tiwari, Arun K. Tiwari, Gwyneth C. Zai, Gwyneth C. Zai, Gwyneth C. Zai, Natalie Freeman, Jennie G. Pouget, Jennie G. Pouget, James Greco, Maria Tampakeras, Sajid A. Shaikh, Deanna Herbert, Heather Emmerson, Sheraz Y. Cheema, Nicole Braganza, Daniel J. Müller, Daniel J. Müller, Daniel J. Müller, Aristotle N. Voineskos, Aristotle N. Voineskos, Aristotle N. Voineskos, Gary Remington, Gary Remington, Gary Remington, James L. Kennedy, James L. Kennedy, James L. Kennedy   +30 more
doaj   +1 more source

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. [PDF]

Nat Neurosci, 2021
Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC.   +8 more
europepmc   +1 more source

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Nature Communications
Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by problems with movement, balance, and cognition. PSP differs from Alzheimer’s disease (AD) and other diseases, displaying abnormal microtubule-associated protein tau ...
Kurt Farrell, Jack Humphrey, Timothy Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan-Ping Lee, Amanda B. Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, Thomas D. Christie, Robina Afzal, Shrishtee Kandoi, Kristen Whitney, Margaret M. Krassner, Hadley Ressler, SoongHo Kim, Diana Dangoor, Megan A. Iida, Alicia Casella, Ruth H. Walker, Melissa J. Nirenberg, Alan E. Renton, Bergan Babrowicz, Giovanni Coppola, Towfique Raj, Günter U. Höglinger, Ulrich Müller, Lawrence I. Golbe, Huw R. Morris, John Hardy, Tamas Revesz, Tom T. Warner, Zane Jaunmuktane, Kin Y. Mok, Rosa Rademakers, Dennis W. Dickson, Owen A. Ross, Li-San Wang, Alison Goate, Gerard Schellenberg, Daniel H. Geschwind, PSP Genetics Study Group, John F. Crary, Adam Naj   +49 more
doaj   +1 more source

MALDI-TOF-MS Analysis in the Identification of Urine Proteomic Patterns of Gestational Trophoblastic Disease

Metabolites, 2019
Gestational trophoblastic disease (GTD) is a group of highly aggressive, rare tumors. Human chorionic gonadotropin is a common biomarker used in the diagnosis and monitoring of GTD.
Paulina Banach, Paweł Dereziński, Eliza Matuszewska, Jan Matysiak, Hubert Bochyński, Zenon J. Kokot, Ewa Nowak-Markwitz   +6 more
doaj   +1 more source

VLBI and Single Dish Monitoring of 3C84 in the Period of 2009-2011

, 2012
The radio galaxy 3C 84 is a representative of gamma-ray-bright misaligned active galactic nuclei (AGNs) and one of the best laboratories to study the radio properties of the sub-pc jet in connection with the gamma-ray emission.
A. Doi, A. Lähteenmäki, Abdo, Abdo, Abdo, Aleksić, Asada, Brown, Brown, D’Ammando, F. D’Ammando, G. Giovannini, H. Nagai, J. Kataoka, J. León-Tavares, K. Asada, K. Suzuki, Kataoka, Kellermann, Komatsu, León-Tavares, Lister, M. Giroletti, M. Inoue, M. Kino, M. Orienti, M. Tornikoski, Marscher, Nagai, Orienti, O’Dea, S. Kameno, Shepherd, Suzuki, Teräsranta, U. Bach   +35 more
core   +1 more source