Results 121 to 130 of about 712,823 (260)

Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.

The Journal of biological chemistry, 2003
We identified Neisseria meningitidis lipooligosaccharide (LOS) as an acceptor for complement component C4b (C4b). Phosphoethanolamine (PEA) residues on the second heptose (HepII) residue in the LOS core structure formed amide linkages with C4b. PEA at the 6-position of HepII (6-PEA) was more efficient than 3-PEA in binding C4b.
Seppo Meri, J. Claire Wright, Peter A. Rice, Sunita Gulati, Sanjay Ram, Ulrich Vogel, Daniel C. Stein, E. Richard Moxon, Ryan Boden, Andrew D. Cox, Silke Getzlaff, James C. Richards, Jianjun Li, Joyce S. Plested   +13 more
openaire   +3 more sources

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts. [PDF]

, 2017
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of ...
Baumgarth, Nicole, Tracy, Karen E
core   +1 more source

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

PLoS ONE, 2012
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ...
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow   +9 more
doaj   +1 more source

Infektív, genetikai és complement aktivációs tényezők szerepének vizsgálata az autoimmun betegségek patogenezisében = Investigation of the role of infective, genetic and complement activation factor in the pathogenesis of autoimmune disorders [PDF]

, 2008
Az MBL2 gén polimorfizmusa az SLE kialakulásának rizikó faktora. 315 SLE-s betegben és 182 kontrollban az MBL2 polimorfizmust vizsgáltuk. Kimutattuk, hogy az MBL2 polimorfizmusában a homozigóta SLE-s betegekben szignifikánsan fiatalabb életkorban (p=0 ...
Backhauszné dr. Takács, Edit Katalin, Farkas, Henriette, Fekete, Béla, Jakab, László, Kalabay, László, Pozsonyi, Teréz, Temesszentandrási, György, Varga, Lilian Ágnes   +7 more
core  

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Ansar, R, Bonifati, DM, Kishore, U, Nayak, A, Verma, SK   +4 more
core   +3 more sources

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
C. Hertz, R. Bayarri-Olmos, Nikolaj Kirketerp-Møller, S. V. van Putten, Katrine Pilely, M. Skjoedt, P. Garred   +6 more
semanticscholar   +1 more source

Pentraxins in Complement Activation and Regulation

Frontiers in Immunology, 2018
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj   +1 more source

Association between copy number variation of complement component C4 and Graves' disease

Journal of Biomedical Science, 2011
Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling, Chang Chwen-Tzuei, Wan Lei, Liu Yu-Huei, Chen Wen-Chi, Tsai Yuhsin, Tsai Chang-Hai, Tsai Fuu-Jen   +7 more
doaj   +1 more source

A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System [PDF]

, 2010
The complement system is key to innate immunity and its activation is necessary for the clearance of bacteria and apoptotic cells. However, insufficient or excessive complement activation will lead to immune-related diseases. It is so far unknown how the
A Krarup, A Thern, AA Korotaevskiy, AF Zadura, AM Blom, AM Blom, AM Blom, Anna M. Blom, AP Sjoberg, AP Sjoberg, B Dahlback, B Liu, B Selander, Benjamin Leong, Bing Liu, Bow Ho, C Mold, CJ Langmead, D Ricklin, D Sheskin, David Hsu, DH Anderson, DT Fearon, DT Fearon, G Koh, H Hirayama, I Gigli, I Gigli, J Gunawardena, J Scharfstein, J Zhang, Jeak Ling Ding, JH Griffin, Jing Zhang, K Berggard, KP Murphy, KP Murphy, L Marnell, L Truedsson, LM Boerger, M Bozga, M Jaeger, M Matsushita, M Okroj, MH Kaplan, MJ Walport, MJ Walport, MV Suresh, N Rawal, NA van Riel, NV Prasadarao, P. S. Thiagarajan, Pei Yi Tan, PM Ng, R Veerhuis, Rustom Antia, S Hoops, S Jha, S Ram, SR Barnum, Sunil Sethi, T Fujita, T Meri, T Nordstrom, V Kirjavainen, X Ji, Z Fishelson, Z Zi   +67 more
core   +4 more sources

Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack

OncoTarget, 2016
Hepatitis B virus X protein (HBx) plays crucial roles in the development of hepatocellular carcinoma (HCC). We previously showed that HBx protected hepatoma cells from complement attack by activation of CD59.
G. Feng, Jiong Li, Minying Zheng, Zhe Yang, Yun-xia Liu, Shuqin Zhang, L. Ye, Weiying Zhang, Xiao-dong Zhang   +8 more
semanticscholar   +1 more source