Results 131 to 140 of about 8,609 (172)

Decreased Plasma Concentrations of the C4B Complement Protein in Autism

Archives of Pediatrics & Adolescent Medicine, 1994
To determine complement C4 protein concentrations in the plasmas of autistic subjects and their family members.Cross-sectional study.Center for Persons with Disabilities and the Department of Biology, Utah State University, Logan.Forty-two autistic subjects (34 males [81%] and eight females [19%]), 50 of their biologic parents, 21 siblings, and 105 ...
R P, Warren, R A, Burger, D, Odell, A R, Torres, W L, Warren   +4 more
openaire   +2 more sources

Human receptor for C3b/C4b: Complement receptor type I

1987
Publisher Summary Receptor function and protein are shown to reside on cells of the myelomonocytic series, mature B lymphocytes, glomerular podocytes, a small population of T lymphocytes, follicular dendritic cells, and even in plasma. The purification scheme to be described in the chapter has made available amounts of purified CR1 sufficient for ...
W W, Wong, D T, Fearon
openaire   +2 more sources

C4b-Binding protein, a regulatory protein of complement

Immunologic Research, 1991
Despite the wealth of structural and functional information on C4BP, it is clear that several aspects of C4BP biology and regulation under normal conditions and in the acute-phase response remain unresolved. Studies to identify which interleukin and cytokines regulate C4BP expression (both α-and β-chains) are underway in our laboratory.
openaire   +2 more sources

Complement Components C4A and C4B in Human Lupus

2005
For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm, Lee A. Hebert, Daniel J. Birmingham, Brad H. Rovin, C. Yung Yu   +9 more
openaire   +1 more source

Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site.

The Journal of Immunology, 1996
Abstract A key step in the elimination of invading pathogens from the body is the covalent binding of complement proteins C3b and C4b to their surface. However, many pathogens have evolved mechanisms to avoid the complement system of the host. Understanding how these mechanisms work may lead to more efficacious forms of therapy.
P, Accardo, P, Sánchez-Corral, O, Criado, E, García, S, Rodríguez de Córdoba   +4 more
openaire   +2 more sources

Glomerular deposition of the complement C4 isotypes C4A and C4B in glomerulonephritis

Nephrology Dialysis Transplantation, 1996
Complement C4 is a component of the classical complement pathway, which is a major mediator of inflammation in many forms of glomerulonephritis. The two isoforms of C4-C4A and C4B-differ in their physicochemical and functional properties.The glomerular deposition of C4A and C4B was investigated in 39 cases of glomerulonephritis with classical pathway ...
K, Lhotta, A, Schlogl, F, Kronenberg, M, Joannidis, P, Konig   +4 more
openaire   +2 more sources

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients

Current Alzheimer Research, 2017
Background/Objectives: Increasing evidence suggests the importance of neuroinflammation in the pathogenesis of Alzheimer’s disease (AD), which is a complex neurodegenerative disorder. Complement activation occurs in the brain of patients with AD and seems to contribute to an important local inflammatory state. Increased expression of the fourth serum
Michele, Zorzetto, Francesca, Datturi, Laura, Divizia, Cristiana, Pistono, Ilaria, Campo, Annalisa, De Silvestri, Mariaclara, Cuccia, Giovanni, Ricevuti   +7 more
openaire   +2 more sources

Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes

Current Protocols in Immunology, 2005
AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
Erwin K, Chung, Yee Ling, Wu, Yan, Yang, Bi, Zhou, C Yung, Yu   +4 more
openaire   +2 more sources

Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae

Molecular Immunology, 2010
The Lyme disease spirochetes, Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, are tick-borne pathogens that can cause chronic disseminated infections. To survive in the human host borreliae need to evade the immune system. It is already well known that B. burgdorferi ss. and B.
Johanna, Pietikäinen, Taru, Meri, Anna M, Blom, Seppo, Meri   +3 more
openaire   +2 more sources

cDNA structure of rabbit C4b-binding protein α-chain. Preserved sequence motive in complement regulatory protein modules which bind C4b

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
A full length cDNA clone for the alpha-chain of the rabbit complement regulatory protein C4b-binding protein (C4BP) was isolated from a liver cDNA library. The clone encoded an open reading frame of 597 amino acids, which included a signal peptide, eight short consensus repeats (SCR) and a carboxy terminal non-repeat region.
P, García de Frutos, B, Dahlbäck
openaire   +2 more sources