Results 141 to 150 of about 8,609 (172)
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Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?
Molecular Immunology, 2004The complement system constitutes an important component of the defence against foreign organisms, functioning both in innate and adaptive immune systems. It is potentially harmful also to the own organism and is therefore tightly regulated by a number of membrane-bound and soluble factors.
Anna M, Blom +2 more
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The Interaction between Anticoagulant Protein S and Complement Regulatory C4b-binding Protein (C4BP)
Trends in Cardiovascular Medicine, 2000An important mechanism of regulation of blood coagulation is the anticoagulant protein C pathway. In this pathway, the anticoagulant activity of activated protein C is increased by its cofactor protein S. The cofactor activity of protein S can be regulated by binding to complement regulatory C4b-binding protein (C4BP).
van de Poel, R. H. +2 more
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Evaluation of Complement-Dependent Cytotoxicity Using ATP Measurement and C1q/C4b Binding
2013One of the major issues for antibody treatment is enhancement of efficacy. Recent studies have highlighted the important role of effector functions in improvement of antibody therapy. Among effector functions, complement-dependent cytotoxicity (CDC), which induces cell lysis by a cascade of activation triggered by the binding of C1q subunits to the Fc ...
Lucile, Broyer +2 more
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Alternative complement pathway activation by C4b deposited during classical pathway activation.
The Journal of Immunology, 1986Abstract Sheep erythrocytes (E) sensitized with anti-E antibody (A) were reacted with guinea pig C1 (C1gp) and human C4 (C4hu) or guinea pig C4 (C4gp) to prepare EAC1, 4b. Treatment of the EAC1, 4b with a buffer containing EDTA removes C1rgp and C1sgp, resulting in the formation of EAC4b. EAC4b prepared in this way were found to be lysed
M, Matsushita, H, Okada
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Complement receptors (C3b, C4b/C3d) unbalance on CLL lymphocytes.
Bollettino dell'Istituto sieroterapico milanese, 1977A study of lymphocytes bearing C3b, C4b and C3d complement receptor (CRL) was performed on human peripheral blood from 16 healthy donors and 12 patients affected with Chronic Lymphatic Leukemia (CLL). In the latter group a clear rise of C3dCRL was demonstrated, when compared with immunoadherence receptors bearing lymphocytes.
B, Perussia +3 more
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THE FREQUENCY OF C4B VARIANTS OF COMPLEMENT IN FAMILIAL AND SPORADIC ALZHEIMER DISEASE
Alzheimer Disease & Associated Disorders, 1987A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals.
T D, Bird +5 more
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Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris
Immunology Letters, 2002Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B.
Maria, Cisło +6 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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