Results 171 to 180 of about 424,323 (243)

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

Chemistry – A European Journal, EarlyView.
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang, Nemanja Djokovic, Alexander Herr, Anna Wacker, Emily Swanson Hay, Daniel Santana, Amanda E. Hargrove, Harald Schwalbe, Katarina Nikolic, Frank Abendroth, Olalla Vázquez   +10 more
wiley   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, EarlyView.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

Chemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil, Bruno Di Geronimo, Toma Kashima, Akihiro Ishiwata, Katsunori Tanaka, Kiyotaka Fujita, Shinya Fushinobu, Pedro A. Sánchez‐Murcia   +7 more
wiley   +1 more source

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

Chemistry – A European Journal, EarlyView.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall, Caroline Brinkmann, Jana Langosch, Anke Nieß, Norbert Sewald   +4 more
wiley   +1 more source

Do CSR Committees Pay Off? Direct and Indirect Links to Financial and ESG Performance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Corporate boards increasingly delegate sustainability oversight to dedicated CSR committees, yet evidence on whether these committees improve corporate performance remains mixed. This study argues that part of this inconsistency arises because prior research often emphasizes overall associations between CSR committees and performance without ...
Ana Isabel Lopes
wiley   +1 more source

Supplier Environmental Assessment in Sustainability Reporting: Evidence From Top ESG‐Performing Brazilian Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the maturity of supplier‐related environmental disclosures in sustainability reports of top environmental, social, and governance (ESG)‐performing Brazilian companies. A content analysis of 67 reports from firms listed on the Corporate Sustainability Index (CSI) was conducted using the CRITIC method to weight disclosure ...
João Vyctor Brás dos Santos, Tiago F. A. C. Sigahi, Deoclécio Junior Cardoso da Silva, Silvia Regina Stuchi Cruz, Milena Pavan Serafim, Walter Leal Filho, Rosley Anholon   +6 more
wiley   +1 more source

Financial Health and Environmental Transparency in the Catalan Pharmaceutical Sector (2019–2023)

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between financial health (2019–2023) and the transparency of environmental information disclosure in leading Catalan pharmaceutical companies. Based on an economic–financial analysis of financial statements and environmental information reported in accordance with the European Sustainability Reporting ...
Núria Arimany‐Serrat, Eulàlia Massana‐Molera, Jesica Ana Menendez‐Signorini, Carme Viladecans‐Riera   +3 more
wiley   +1 more source

Assessing Sustainability Performance in the Life Insurance Industry: An Integrated Sustainability Balanced Scorecard Framework Under q‐Rung Orthopair Fuzzy Information

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Assessing the sustainability performance of life insurers has become increasingly important, as long‐term competitiveness depends not only on financial soundness but also on environmental, social, organizational, and governance‐related capabilities.
Özcan Işık, İbrahim Adalar
wiley   +1 more source

Internationalising the teacher education curriculum: An analysis of syllabi and student experiences

The Curriculum Journal, EarlyView.
Abstract Internationalisation has increasingly become a key dimension of quality in initial teacher education (ITE) programmes. Although it is recognised as a means to strengthen future teachers' competencies and expand their professional knowledge, it remains underdeveloped in practice.
Nafsika Alexiadou, Mai Trang Vu
wiley   +1 more source

Low‐Temperature in Situ Upgrading of Ultra‐Deep Heavy Oil Using Ni–Ce/MOF–OTf Superacid Catalysts to Enhance Energy Utilization and Sustainability

EcoEnergy, EarlyView.
A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang, Ji‐Xiang Guo, Qiming Huang, Kunpeng Li, Chi Li, Yajie Wu   +5 more
wiley   +1 more source